2025年10月14日出版的《自然—神经科学》杂志发表了荷兰莱顿大学Matthias J. P. van Osch小组的最新成果，他们的研究开发出了MRI测量人类脑脊液活动的区域特异性驱动因素。

在这里，课题组人员提出了一种非侵入性的脑脊液特异性磁共振成像技术（CSF- selective T2-prepared REadout with Acceleration and mobility -encoding），该技术可以详细测量人体脑脊液的活动性，精确到位于穿透血管周围的血管周围，靠近蛋白质生产位点的血管间隙水平。该课题组发现了脑脊液流动性的区域特异性驱动因素，并证明脑脊液流动性可以通过血管舒张而增加。

此外，该课题组研究人员发现脑淀粉样血管病（一种与清除障碍相关的脑部疾病）患者存在区域特异性脑脊液活动性改变。这项技术的可用性为研究CSF介导的清除在神经变性和睡眠中的影响开辟了途径。

据了解，许多神经系统疾病的特点是大脑中有毒蛋白质的积累。这种积聚与薄壁组织清除不当有关。最近的发现强调了血管周围空间，即充满脑脊液（CSF）的空间，是大脑清除的通道。驱动脑脊液在血管周围空间内移动的力量仍有争议。

附：英文原文

Title: Region-specific drivers of CSF mobility measured with MRI in humans

Author: Hirschler, Lydiane, Runderkamp, Bobby A., Decker, Andreas, van Harten, Thijs W., Scheyhing, Paul, Ehses, Philipp, Petitclerc, Lonie, Layer, Julia, Pracht, Eberhard, Coolen, Bram F., van der Zwaag, Wietske, Stcker, Tony, Vollmuth, Philipp, Paech, Daniel, Effland, Alexander, van Walderveen, Marianne A. A., Radbruch, Alexander, van Buchem, Mark A., Petzold, Gabor C., van Veluw, Susanne J., Caan, Matthan W. A., Deike, Katerina, van Osch, Matthias J. P.

Issue&Volume: 2025-10-14

Abstract: Many neurological diseases are characterized by the accumulation of toxic proteins in the brain. This accumulation has been associated with improper clearance from the parenchyma. Recent discoveries highlighted perivascular spaces, which are cerebrospinal fluid (CSF)-filled spaces, as the channels of brain clearance. The forces driving CSF mobility within perivascular spaces are still debated. Here we present a noninvasive, CSF-specific magnetic resonance imaging technique (CSF-Selective T2-prepared REadout with Acceleration and Mobility-encoding) that enables detailed in vivo measurement of CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels, which is close to protein production sites. We find region-specific drivers of CSF mobility and demonstrate that CSF mobility can be increased by entraining vasomotion. Furthermore, we find region-specific CSF mobility alterations in patients with cerebral amyloid angiopathy, a brain disorder associated with clearance impairment. The availability of this technique opens up avenues to investigate the impact of CSF-mediated clearance in neurodegeneration and sleep.

DOI: 10.1038/s41593-025-02073-3

Source: https://www.nature.com/articles/s41593-025-02073-3