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情绪感染期间缰核释放血清素可促进恢复力
作者:小柯机器人 发布时间:2024/9/7 18:12:16

瑞士洛桑大学Manuel Mameli团队近期取得重要工作进展,他们研究提出,情绪感染期间缰核释放血清素可促进恢复力。相关研究成果2024年9月6日在线发表于《科学》杂志上。

据介绍,负面情绪传染(目睹他人处于困境)会影响个人的情绪反应。然而,它是否会在面对未来威胁时形成应对策略仍然未知。

研究人员发现,短暂观察到同种动物受到伤害的小鼠会变得恢复力增强,在经历了不利经历后能够承受行为绝望。负面情绪感染期间的光度记录显示,外侧缰核中血清素(5-HT)的释放增加。

尽管5-羟色胺和情绪感染会减少缰核爆发,但限制5-羟色胺的合成会阻止爆发可塑性。增强中缝至缰核5-HT足以重现恢复力。相比之下,减少缰核中的5-HT释放使得目睹同种异体的痛苦无法促进逆境后的恢复力表型。

总之,这一研究表明,5-HT支持替代情绪,并通过调节缰核神经元活动的特定模式来增强恢复力。

附:英文原文

Title: Serotonin release in the habenula during emotional contagion promotes resilience

Author: Sarah Mondoloni, Patricia Molina, Salvatore Lecca, Cheng-Hsi Wu, Léo Michel, Denys Osypenko, Fanchon Cachin, Meghan Flanigan, Mauro Congiu, Arnaud L. Lalive, Thomas Kash, Fei Deng, Yulong Li, Manuel Mameli

Issue&Volume: 2024-09-06

Abstract: Negative emotional contagion—witnessing others in distress—affects an individual’s emotional responsivity. However, whether it shapes coping strategies when facing future threats remains unknown. We found that mice that briefly observe a conspecific being harmed become resilient, withstanding behavioral despair after an adverse experience. Photometric recordings during negative emotional contagion revealed increased serotonin (5-HT) release in the lateral habenula. Whereas 5-HT and emotional contagion reduced habenular burst firing, limiting 5-HT synthesis prevented burst plasticity. Enhancing raphe-to-habenula 5-HT was sufficient to recapitulate resilience. In contrast, reducing 5-HT release in the habenula made witnessing a conspecific in distress ineffective to promote the resilient phenotype after adversity. These findings reveal that 5-HT supports vicarious emotions and leads to resilience by tuning definite patterns of habenular neuronal activity.

DOI: adp3897

Source: https://www.science.org/doi/10.1126/science.adp3897

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:63.714