美国布莱根妇女医院Shan H. Siddiqi等研究人员发现一个源于退伍军人局部脑损伤的，PTSD症状非侵入性神经调节的潜在靶点。相关论文于2024年9月24日在线发表于国际学术期刊《自然—神经科学》。

研究人员分析了三个数据集，来研究与军事退伍军人创伤后应激障碍（PTSD）因果相关的脑回路。在有穿透性创伤性脑损伤的退伍军人中，减少PTSD概率的损伤位置优先连接到一个包含内侧前额叶皮层、杏仁体和前外侧颞叶的回路。

在没有损伤的退伍军人中，PTSD则与该回路内连接性的增加特异相关。经颅磁刺激后，该回路功能连接性的降低与症状减轻相关，尽管该回路并未直接靶向。这一基于损伤的“PTSD回路”，可能为有PTSD的退伍军人的神经调节临床试验提供靶点。

据了解，PTSD的神经调节试验结果不一，最佳神经解剖靶点尚不明确。

附：英文原文

Title: A potential target for noninvasive neuromodulation of PTSD symptoms derived from focal brain lesions in veterans

Author: Siddiqi, Shan H., Philip, Noah S., Palm, Stephan T., Carreon, David M., Arulpragasam, Amanda R., Barredo, Jennifer, Bouchard, Heather, Ferguson, Michael A., Grafman, Jordan H., Morey, Rajendra A., Fox, Michael D.

Issue&Volume: 2024-09-24

Abstract: Neuromodulation trials for the treatment of posttraumatic stress disorder (PTSD) have yielded mixed results, and the optimal neuroanatomical target remains unclear. Here we analyzed three datasets to study brain circuitry causally linked to PTSD in military veterans. In veterans with penetrating traumatic brain injury, lesion locations that reduced probability of PTSD were preferentially connected to a circuit including the medial prefrontal cortex, amygdala and anterolateral temporal lobe. In veterans without lesions, PTSD was specifically associated with increased connectivity within this circuit. Reduced functional connectivity within this circuit after transcranial magnetic stimulation correlated with symptom reduction, even though the circuit was not directly targeted. This lesion-based ‘PTSD circuit’ may serve as a target for clinical trials of neuromodulation in veterans with PTSD.

DOI: 10.1038/s41593-024-01772-7

Source: https://www.nature.com/articles/s41593-024-01772-7