南京工业大学郭凯团队报道了烯还原酶催化简单环己酮芳构化制酚。相关研究成果于2024年8月6日发表在《德国应用化学》。

环己酮直接芳构化合成取代酚是现代合成化学中的一个重大挑战。

该文中，研究人员描述了一种新型的烯还原酶（TsER）催化体系，该体系将取代的环己酮转化为相应的酚类。

该过程涉及环己酮六元环内两个饱和碳-碳键的连续脱氢，并利用分子氧驱动反应循环。它展示了一种合成取代酚的通用且高效的方法，为现有的化学方法提供了有价值的补充。

附：英文原文

Title: Ene-Reductase-Catalyzed Aromatization of Simple Cyclohexanones to Phenols

Author: Jie Chen, Shaofang Qi, Zhiguo Wang, Liran Hu, Jialing Liu, Guixiang Huang, Yongzhen Peng, Zheng Fang, Qi Wu, Yujing Hu, Kai Guo

Issue&Volume: 2024-08-06

Abstract: Direct aromatization of cyclohexanones to synthesize substituted phenols represents a significant challenge in modern synthetic chemistry. Herein, we describe a novel ene-reductase (TsER) catalytic system that converts substituted cyclohexanones into the corresponding phenols. This process involves the successive dehydrogenation of two saturated carbon-carbon bonds within the six-membered ring of cyclohexanones and utilizes molecular oxygen to drive the reaction cycle. It demonstrates a versatile and efficient approach for the synthesis of substituted phenols, providing a valuable complement to existing chemical methodologies.

DOI: 10.1002/anie.202408359

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202408359