陆军军医大学牛建钦等研究人员合作总结中枢神经系统中的少突胶质前体细胞。该论文于2024年7月23日在线发表在国际学术期刊《神经科学通报》上。

研究人员表示，少突胶质前体细胞（OPC） 是中枢神经系统（CNS）中一个异质性多能群体，它们在胚胎发育过程中出现，并作为常驻细胞存在于成年大脑实质中。OPC能够生成少突胶质细胞，参与髓鞘形成。近期的研究进展更新了人们对OPC生物学的认识，发现了少突胶质细胞的新标记物、OPC的髓鞘独立作用以及OPC发展的调控机制。

研究人员探讨了有关OPC身份的最新知识、它们在健康和疾病中的多面角色，以及涉及其发育阶段的调控机制，这些内容有望进一步加深对OPC的理解，并引起OPC生物学领域的关注。

附：英文原文

Title: A New Acquaintance of Oligodendrocyte Precursor Cells in the Central Nervous System

Author: Ma, Zexuan, Zhang, Wei, Wang, Chenmeng, Su, Yixun, Yi, Chenju, Niu, Jianqin

Issue&Volume: 2024-07-23

Abstract: Oligodendrocyte precursor cells (OPCs) are a heterogeneous multipotent population in the central nervous system (CNS) that appear during embryogenesis and persist as resident cells in the adult brain parenchyma. OPCs could generate oligodendrocytes to participate in myelination. Recent advances have renewed our knowledge of OPC biology by discovering novel markers of oligodendroglial cells, the myelin-independent roles of OPCs, and the regulatory mechanism of OPC development. In this review, we will explore the updated knowledge on OPC identity, their multifaceted roles in the CNS in health and diseases, as well as the regulatory mechanisms that are involved in their developmental stages, which hopefully would contribute to a further understanding of OPCs and attract attention in the field of OPC biology.

DOI: 10.1007/s12264-024-01261-8

Source: https://link.springer.com/article/10.1007/s12264-024-01261-8