美国华盛顿大学Keith B. Hengen团队近期取得重要工作进展,他们研究提出,大脑状态的非振荡、毫秒级嵌入提供了对行为的洞察。相关研究成果2024年7月15日在线发表于《自然—神经科学》杂志上。
据介绍,大脑状态最稳健、最可靠的特征是0.1到20赫兹之间的节律。
研究人员讨论了大脑状态的基本单位可能是毫秒和微米的可能性。通过分析24小时内记录在10个小鼠大脑区域的高分辨率神经活动,研究人员发现大脑状态可以可靠地识别(嵌入)在快速、无振荡的活动中。睡眠和清醒状态可以从100µm脑组织中采样的100到101 ms的神经元活动中进行分类。
与典型节律相反,这种嵌入在1000Hz以上持续存在。这种高频嵌入对亚稳态、尖波波纹和皮质开关状态具有稳健性。单个区域独立于大脑的其他部分间歇性地切换状态,这种短暂的状态不连续性与短暂的行为不连续性相吻合。
总之,这一研究结果表明,大脑中的基本状态单位与神经元计算的空间和时间尺度相一致。
附:英文原文
Title: A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior
Author: Parks, David F., Schneider, Aidan M., Xu, Yifan, Brunwasser, Samuel J., Funderburk, Samuel, Thurber, Danilo, Blanche, Tim, Dyer, Eva L., Haussler, David, Hengen, Keith B.
Issue&Volume: 2024-07-15
Abstract: The most robust and reliable signatures of brain states are enriched in rhythms between 0.1 and 20Hz. Here we address the possibility that the fundamental unit of brain state could be at the scale of milliseconds and micrometers. By analyzing high-resolution neural activity recorded in ten mouse brain regions over 24h, we reveal that brain states are reliably identifiable (embedded) in fast, nonoscillatory activity. Sleep and wake states could be classified from 100 to 101ms of neuronal activity sampled from 100μm of brain tissue. In contrast to canonical rhythms, this embedding persists above 1,000Hz. This high-frequency embedding is robust to substates, sharp-wave ripples and cortical on/off states. Individual regions intermittently switched states independently of the rest of the brain, and such brief state discontinuities coincided with brief behavioral discontinuities. Our results suggest that the fundamental unit of state in the brain is consistent with the spatial and temporal scale of neuronal computation.
DOI: 10.1038/s41593-024-01715-2
Source: https://www.nature.com/articles/s41593-024-01715-2
Nature Neuroscience:《自然—神经科学》,创刊于1998年。隶属于施普林格·自然出版集团,最新IF:28.771
官方网址:https://www.nature.com/neuro/
投稿链接:https://mts-nn.nature.com/cgi-bin/main.plex