苏州大学牛政团队报道了基于金属-有机框架的受挫路易斯对选择性还原硝基烯烃为硝基烷烃。相关研究成果于2024年6月20日发表在《美国化学会杂志》。

硝基烷烃是合成药物、农用化学品和功能材料的重要中间体。迄今为止，硝基烷烃主要由可回收性差的均相催化剂如贵过渡金属催化剂制备。

该文中，研究人员提出了一种金属-有机框架受挫路易斯对（MOF-FLP）多相催化剂，用于在中等反应条件下选择性地将硝基烯烃还原为硝基烷烃。与均相FLP催化剂相比，MOF富集效应可以显著提高催化效率。得益于FLP和MOF之间的强相互作用，MOF-FLP催化剂表现出优异的可回收性。

该项工作不仅为硝基烷烃的合成提供了一条方便的途径，而且展示了多孔多相FLP催化剂的潜力，为未来的催化设计策略提供了灵感。

附：英文原文

Title: Metal–Organic Frameworks-Based Frustrated Lewis Pairs for Selective Reduction of Nitroolefins to Nitroalkanes

Author: Zhuoyi Hu, Zi-Wen Fan, Ze-Ming Xu, Yueyue Wu, Han-Wen Zhang, Ya-Li Huang, Zheng Niu

Issue&Volume: June 20, 2024

Abstract: Nitroalkanes serve as essential intermediates in the synthesis of pharmaceuticals, agrochemicals, and functional materials. To date, nitroalkanes are mainly prepared from homogeneous catalysts such as noble transition metal catalysts with poor recyclability. Herein, we propose a metal–organic framework-frustrated Lewis pair (MOF-FLP) heterogeneous catalyst for selectively reducing nitroolefins to nitroalkanes under moderate reaction conditions. MOF enrichment effect can significantly improve the catalytic efficiency compared to homogeneous FLP catalysts. Benefiting from the strong interaction between FLP and MOF, the MOF-FLP catalyst exhibits outstanding recyclability. This work not only provides a convenient route for nitroalkane synthesis but also showcases the potential of porous heterogeneous FLP catalysts, offering inspiration for future catalytic design strategies.

DOI: 10.1021/jacs.4c03756

Source: https://pubs.acs.org/doi/abs/10.1021/jacs.4c03756