中国科学院深圳先进技术研究院王立平等研究人员合作绘制出小鼠的性别二态性肾-脑连接图谱。2024年6月19日，《神经科学通报》杂志在线发表了这项成果。

据介绍，肾脏是帮助维持体内平衡的重要器官，其功能受神经系统调节。尽管中枢自律神经核与肾脏之间存在解剖学上的多突触联系，但目前仍不清楚雌雄小鼠神经系统与肾皮质和髓质之间的神经联系是否存在差异。

附：英文原文

Title: Sex-Dimorphic Kidney-Brain Connectivity Map of Mice

Author: Li, Xulin, Zhou, Yuan, Wang, Feng, Wang, Liping

Issue&Volume: 2024-06-19

Abstract: The kidneys are essential organs that help maintain homeostasis, and their function is regulated by the neural system. Despite the anatomical multi-synaptic connection between the central autonomic nuclei and the kidneys, it remains unclear whether there are any variations in neural connections between the nervous systems and the renal cortex and medulla in male and female mice. Here, we used the pseudorabies virus to map the central innervation network of the renal cortex and medulla in both sexes. The data revealed that specific brain regions displayed either a contralateral-bias or ipsilateral-bias pattern while kidney-innervating neurons distributed symmetrically in the midbrain and hindbrain. Sex differences were observed in the distribution of neurons connected to the left kidney, as well as those connected to the renal cortex and medulla. Our findings provide a comprehensive understanding of the brain-kidney network in both males and females and may help shed light on gender differences in kidney function and disease susceptibility in humans.

DOI: 10.1007/s12264-024-01240-z

Source: https://link.springer.com/article/10.1007/s12264-024-01240-z