香港科技大学唐本忠团队报道了基于BF₂桥接富烯二聚体的1064nm激光驱动的高级光热剂用于深部肿瘤治疗。相关研究成果发表在2024年6月13日出版的《德国应用化学》。

具有位于第二近红外（NIR-II，1000-1700nm）窗口的吸收带的小型有机光热试剂（PTAs），对于有效对抗深层肿瘤是非常理想的。然而，很少报道的NIR-II吸收PTAs仍然存在低摩尔消光系数（MEC，ε）、化学稳定性和光稳定性不足以及治疗过程中所需的高光功率密度的问题。

该文中，研究人员开发了一系列二氟化硼桥接的氮杂富烯二聚体受体集成的小型有机PTAs。π-共轭的氮杂富烯二聚体骨架中的B-N配位键赋予了它强大的吸电子能力，促进了具有NIR-II吸收的强供体-受体-供体（D-A-D）结构PTAs。值得注意的是，PTAs即OTTBF显示出高MEC（7.21×10⁴ M^-1 cm^-1）、超高化学稳定性和光稳定性。

在封装到水分散性纳米颗粒中后，OTTBF NPs在1064nm的光密度低至0.7W cm^-2的照射下可以实现显著的光热转换效果，这是我们所知的PTT工艺中使用的最低NIR-II光功率。此外，OTTBF NPs已成功应用于1064nm激光下的体外和体内深层癌症治疗。

该项研究为生物医学应用的多功能D-A-D结构NIR-II吸收有机PTAs的未来探索提供了见解。

附：英文原文

Title: BF2-Bridged Azafulvene Dimer-Based 1064 nm Laser-Driven Superior Photothermal Agent for Deep-Seated Tumor Therapy

Author: Mingwang Yang, Xinwen Ou, Jianwei Li, Jianwei Sun, Zheng Zhao, Jacky W. Y. Lam, Jiangli Fan, Ben Zhong Tang

Issue&Volume: 2024-06-13

Abstract: Small organic photothermal reagents (PTAs) with absorption bands located in the second near-infrared (NIR-II, 1000-1700 nm) window are highly desirable for effectively combating deep-seated tumors. However, the rarely reported NIR-II absorbing PTAs still suffer from a low molar extinction coefficient (MEC, ε), inadequate chemostability and photostability, as well as the high light power density required during the therapeutic process. Herein, we developed a series of boron difluoride bridged azafulvene dimer acceptor-integrated small organic PTAs. The B-N coordination bonds in the π-conjugated azafulvene dimer backbone endow it the strong electron-withdrawing ability, facilitating the vigorous donor-acceptor-donor (D-A-D) structure PTAs with NIR-II absorption. Notably, the PTAs namely OTTBF shows high MEC (7.21× 104 M-1 cm-1), ultrahigh chemo- and photo-stability. After encapsulated into water-dispersible nanoparticles, OTTBF NPs can achieve remarkable photothermal conversion effect under 1064 nm irradiation with a light density as low as 0.7 W cm-2, which is the lowest reported NIR-II light power used in PTT process as we know. Furthermore, OTTBF NPs have been successfully applied for in vitro and in vivo deep-seated cancer treatments under 1064 nm laser. This study provides an insight into the future exploration of versatile D-A-D structured NIR-II absorption organic PTAs for biomedical applications.

DOI: 10.1002/anie.202407307

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202407307