美国H. Lee Moffitt癌症中心Filippo Veglia研究组发现，葡萄糖驱动的组蛋白乳酸化促进胶质母细胞瘤中单核细胞衍生巨噬细胞的免疫抑制活性。相关论文于2024年5月3日在线发表在《免疫》杂志上。

研究人员表示，免疫抑制巨噬细胞限制了胶质母细胞瘤（GBM）的抗癌免疫。

附：英文原文

Title: Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma

Author: Alessandra De Leo, Alessio Ugolini, Xiaoqing Yu, Fabio Scirocchi, Delia Scocozza, Barbara Peixoto, Angelica Pace, Luca D’Angelo, James K.C. Liu, Arnold B. Etame, Aurelia Rughetti, Marianna Nuti, Antonio Santoro, Michael A. Vogelbaum, Jose R. Conejo-Garcia, Paulo C. Rodriguez, Filippo Veglia

Issue&Volume: 2024-05-03

Abstract: Immunosuppressive macrophages restrict anti-cancer immunity in glioblastoma (GBM).Here, we studied the contribution of microglia (MGs) and monocyte-derived macrophages(MDMs) to immunosuppression and mechanisms underlying their regulatory function. MDMsoutnumbered MGs at late tumor stages and suppressed T cell activity. Molecular andfunctional analysis identified a population of glycolytic MDM expressing GLUT1 withpotent immunosuppressive activity. GBM-derived factors promoted high glycolysis, lactate,and interleukin-10 (IL-10) production in MDMs. Inhibition of glycolysis or lactateproduction in MDMs impaired IL-10 expression and T cell suppression. Mechanistically,intracellular lactate-driven histone lactylation promoted IL-10 expression, whichwas required to suppress T cell activity. GLUT1 expression on MDMs was induced downstreamof tumor-derived factors that activated the PERK-ATF4 axis. PERK deletion in MDM abrogatedhistone lactylation, led to the accumulation of intratumoral T cells and tumor growthdelay, and, in combination with immunotherapy, blocked GBM progression. Thus, PERK-drivenglucose metabolism promotes MDM immunosuppressive activity via histone lactylation.

DOI: 10.1016/j.immuni.2024.04.006

Source: https://www.cell.com/immunity/abstract/S1074-7613(24)00211-5