复旦大学Xiang Zhou等研究人员合作总结了癌症中细胞外囊泡的功能。2024年5月25日，《分子细胞生物学报》在线发表了该论文。

研究人员表示，细胞间的交流可以通过细胞与细胞之间的直接接触和通过分泌可溶性趋化因子、细胞因子和生长因子的间接相互作用来介导。细胞外囊泡（EV）已成为细胞间和细胞与环境间交流的重要媒介。来自肿瘤细胞、免疫细胞和基质细胞的EV可重塑肿瘤微环境，促进癌细胞的存活、增殖、转移、免疫逃避和抗药性。

最重要的是，EV作为天然纳米颗粒，可以通过操作成为癌症靶向治疗的有效传递系统。可以对EV进行设计或改造，以提高其靶向肿瘤和输送治疗物质（如化疗药物、核酸和蛋白质）的能力，从而治疗癌症。

研究人员概述了EV的生物生成和循环，讨论了它们在癌症发展中的作用，并强调了它们作为癌症靶向治疗递送系统的潜力。

附：英文原文

Title: Extracellular vesicles in cancer: Golden goose or trojan horse

Author: Han, Tao, Hao, Qian, Chao, Tengfei, Sun, Qinggang, Chen, Yitian, Gao, Bo, Guan, Liping, Ren, Wenjie, Zhou, Xiang

Issue&Volume: 2024-05-25

Abstract: Intercellular communication can be mediated by direct cell-to-cell contact and indirect interactions through secretion of soluble chemokines, cytokines, and growth factors. Extracellular vesicles (EVs) have emerged as important mediators of cell-to-cell and cell-to-environment communications. EVs from tumor cells, immune cells, and stromal cells can remodel the tumor microenvironment and promote cancer cell survival, proliferation, metastasis, immune evasion, and therapeutic resistance. Most importantly, EVs as natural nanoparticles can be manipulated to serve as a potent delivery system for targeted cancer therapy. EVs can be engineered or modified to improve their ability to target tumors and deliver therapeutic substances, such as chemotherapeutic drugs, nucleic acids, and proteins, for the treatment of cancer. This review provides an overview of the biogenesis and recycling of EVs, discusses their roles in cancer development, and highlights their potential as a delivery system for targeted cancer therapy.

DOI: 10.1093/jmcb/mjae025

Source: https://dx.doi.org/10.1093/jmcb/mjae025