大连医科大学Xiaochi Ma等研究人员合作发现，培养的人体肠道真菌基因组汇编描述肠道真菌生物群的特征及其与常见疾病的相关性。该项研究成果于2024年5月21日在线发表在《细胞》杂志上。
研究人员表示，肠道真菌群落是人类健康的重要组成部分，但其功能和代谢潜力仍未得到充分阐明，这主要是由于参考基因组的可用性有限。
为了填补这一空白，研究人员提出了培养的肠道真菌（CGF）目录，其中包括从健康人粪便中提取的760个真菌基因组。该目录包括跨越48个科的206个物种，其中包括69个以前未被发现的物种。通过分析来自中国和非中国人群的11000多个粪便元基因组，研究人员探索了CGF物种的功能和代谢属性，并利用该目录构建了肠道真菌生物群的系统发育表征。
此外，研究人员还发现了肠道真菌生物群组成中与疾病相关的重要共性变异，并通过动物实验证实了真菌特征与炎症性肠病（IBD）之间的关联。这些资源和发现极大地丰富了人们，对人类肠道真菌生物群的生物多样性和疾病相关性的认识。
附：英文原文
Title: A genomic compendium of cultivated human gut fungi characterizes the gut mycobiome and its relevance to common diseases
Author: Qiulong Yan, Shenghui Li, Qingsong Yan, Xiaokui Huo, Chao Wang, Xifan Wang, Yan Sun, Wenyu Zhao, Zhenlong Yu, Yue Zhang, Ruochun Guo, Qingbo Lv, Xin He, Changliang Yao, Zhiming Li, Fang Chen, Qianru Ji, Aiqin Zhang, Hao Jin, Guangyang Wang, Xiaoying Feng, Lei Feng, Fan Wu, Jing Ning, Sa Deng, Yue An, De-an Guo, Francis M. Martin, Xiaochi Ma
Issue&Volume: 2024-05-21
Abstract: The gut fungal community represents an essential element of human health, yet itsfunctional and metabolic potential remains insufficiently elucidated, largely dueto the limited availability of reference genomes. To address this gap, we presentedthe cultivated gut fungi (CGF) catalog, encompassing 760 fungal genomes derived fromthe feces of healthy individuals. This catalog comprises 206 species spanning 48 families,including 69 species previously unidentified. We explored the functional and metabolicattributes of the CGF species and utilized this catalog to construct a phylogeneticrepresentation of the gut mycobiome by analyzing over 11,000 fecal metagenomes fromChinese and non-Chinese populations. Moreover, we identified significant common disease-relatedvariations in gut mycobiome composition and corroborated the associations betweenfungal signatures and inflammatory bowel disease (IBD) through animal experimentation.These resources and findings substantially enrich our understanding of the biologicaldiversity and disease relevance of the human gut mycobiome.
DOI: 10.1016/j.cell.2024.04.043
Source: https://www.cell.com/cell/abstract/S0092-8674(24)00469-0