2024年5月13日，美国波士顿基因公司Michael F. Goldberg研究团队在《癌细胞》杂志发表论文，综合外周血免疫分型揭示癌症患者具有免疫疗法反应特征的五种免疫分型。

为了满足这一尚未得到满足的需求，研究人员开发了一种免疫分析平台，利用多参数流式细胞仪来描述健康捐献者和晚期癌症患者外周血中免疫细胞的异质性。通过无监督聚类，研究人员确定了五种具有独特细胞类型分布和基因表达谱的免疫类型。用同样的方法对17800个开源转录组进行的独立分析证实了这些发现。研究人员开发了基于连续免疫类型的特征得分，用于将全身免疫与患者对不同癌症治疗（包括免疫疗法）的反应联系起来，并对预后和预测进行分析。这些方法和研究结果表明，一种简单的血液检测可作为一种灵活的工具，根据全身免疫分层将癌症患者分为不同的治疗反应组。

附：英文原文

Title: Comprehensive peripheral blood immunoprofiling reveals five immunotypes with immunotherapy response characteristics in patients with cancer

Author: Daniiar Dyikanov, Aleksandr Zaitsev, Tatiana Vasileva, Iris Wang, Arseniy A. Sokolov, Evgenii S. Bolshakov, Alena Frank, Polina Turova, Olga Golubeva, Anna Gantseva, Anna Kamysheva, Polina Shpudeiko, Ilya Krauz, Mary Abdou, Madison Chasse, Tori Conroy, Nicholas R. Merriam, Julia E. Alesse, Noel English, Boris Shpak, Anna Shchetsova, Evgenii Tikhonov, Ivan Filatov, Anastasia Radko, Anastasiia Bolshakova, Anastasia Kachalova, Nika Lugovykh, Andrey Bulahov, Anastasiia Kilina, Syimyk Asanbekov, Irina Zheleznyak, Pavel Skoptsov, Evgenia Alekseeva, Jennifer M. Johnson, Joseph M. Curry, Alban J. Linnenbach, Andrew P. South, EnJun Yang, Kirill Morozov, Anastasiya Terenteva, Lira Nigmatullina, Dmitry Fastovetz, Anatoly Bobe, Linda Balabanian, Krystle Nomie, Sheila T. Yong, Christopher J.H. Davitt, Alexander Ryabykh, Olga Kudryashova, Cagdas Tazearslan, Alexander Bagaev, Nathan Fowler, Adam J. Luginbuhl, Ravshan I. Ataullakhanov, Michael F. Goldberg

Issue&Volume: 2024/05/13

Abstract: The lack of comprehensive diagnostics and consensus analytical models for evaluating the status of a patient’s immune system has hindered a wider adoption of immunoprofiling for treatment monitoring and response prediction in cancer patients. To address this unmet need, we developed an immunoprofiling platform that uses multiparameter flow cytometry to characterize immune cell heterogeneity in the peripheral blood of healthy donors and patients with advanced cancers. Using unsupervised clustering, we identified five immunotypes with unique distributions of different cell types and gene expression profiles. An independent analysis of 17,800 open-source transcriptomes with the same approach corroborated these findings. Continuous immunotype-based signature scores were developed to correlate systemic immunity with patient responses to different cancer treatments, including immunotherapy, prognostically and predictively. Our approach and findings illustrate the potential utility of a simple blood test as a flexible tool for stratifying cancer patients into therapy response groups based on systemic immunoprofiling.

DOI: 10.1016/j.ccell.2024.04.008

Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(24)00132-6