复旦大学Ting Ni研究团队揭示人类癌症中内含子多聚腺苷酸化的状况和临床意义。相关论文于2024年5月11日在线发表在《遗传学报》上。

附：英文原文

Title: The landscape and clinical relevance of intronic polyadenylation in human cancers

Author: Ting Ni a c

Issue&Volume: 2024/05/11

Abstract: Intronic polyadenylation (IPA) is an RNA 3' end processing event which has been reported to play important roles in cancer development. However, the comprehensive landscape of IPA events across various cancer types is lacking. Here, we apply IPAFinder to identify and quantify IPA events in 10,383 samples covering all 33 cancer types from The Cancer Genome Atlas (TCGA) project. We totally identify 21,835 IPA events, almost half of which are ubiquitously expressed. We identify 2,761 unique dynamically changed IPA events across cancer types. Furthermore, we observe 8,855 non-redundant clinically relevant IPA events, which could potentially be used as prognostic indicators. Our analysis also reveals that dynamic IPA usage within cancer signaling pathways may affect drug response. Finally, we develop a user-friendly data portal, IPACancer Atlas (http://www.tingni-lab.com/Pancan_IPA/), to search and explore IPAs in cancer.

DOI: 10.1016/j.jgg.2024.04.014

Source: https://www.sciencedirect.com/science/article/abs/pii/S1673852724000997