美国普渡大学马渐新等研究人员合作发现，长非编码RNA是大豆多种驯化性状和叶蝉抗性的基础。相关论文于2024年4月29日在线发表在《自然—遗传学》杂志上。

据介绍，人们对lncRNA的起源和功能仍然知之甚少。

附：英文原文

Title: Long noncoding RNAs underlie multiple domestication traits and leafhopper resistance in soybean

Author: Wang, Weidong, Duan, Jingbo, Wang, Xutong, Feng, Xingxing, Chen, Liyang, Clark, Chancelor B., Swarm, Stephen A., Wang, Jinbin, Lin, Sen, Nelson, Randall L., Meyers, Blake C., Feng, Xianzhong, Ma, Jianxin

Issue&Volume: 2024-04-29

Abstract: The origin and functionality of long noncoding RNA (lncRNA) remain poorly understood. Here, we show that multiple quantitative trait loci modulating distinct domestication traits in soybeans are pleiotropic effects of a locus composed of two tandem lncRNA genes. These lncRNA genes, each containing two inverted repeats, originating from coding sequences of the MYB genes, function in wild soybeans by generating clusters of small RNA (sRNA) species that inhibit the expression of their MYB gene relatives through post-transcriptional regulation. By contrast, the expression of lncRNA genes in cultivated soybeans is severely repressed, and, consequently, the corresponding MYB genes are highly expressed, shaping multiple distinct domestication traits as well as leafhopper resistance. The inverted repeats were formed before the divergence of the Glycine genus from the Phaseolus–Vigna lineage and exhibit strong structure–function constraints. This study exemplifies a type of target for selection during plant domestication and identifies mechanisms of lncRNA formation and action.

DOI: 10.1038/s41588-024-01738-2

Source: https://www.nature.com/articles/s41588-024-01738-2