荷兰格罗宁根大学Feringa, Ben L.团队甲报道了酰化提高了光驱动过度拥挤的烯烃衍生旋转分子马达的性能。相关研究成果于2024年4月26日发表在《自然—化学》。

人工分子马达和机器构成了从单个分子运动，到创建集体动态分子系统和响应材料转变的关键要素。以高效率和高选择性操作的人造光驱动分子马达的设计，构成了一个持续的基本挑战。

该文中，研究人员提出了一种基于Rieche甲酰化的高度通用的合成方法，该方法提高了正向光异构化反应的量子产率，同时在单向旋转循环中所涉及的步骤中达到近乎完美的选择性，并大大减少了竞争性的光反应。这种马达很容易以其对映体纯形式获得，并以几乎定量的光转换进行。作为胆甾醇型液晶材料中的可重构手性掺杂剂，它可以很容易地进一步功能化，并优于其直接前身。

附：英文原文

Title: Formylation boosts the performance of light-driven overcrowded alkene-derived rotary molecular motors

Author: Sheng, Jinyu, Danowski, Wojciech, Sardjan, Andy S., Hou, Jiaxin, Crespi, Stefano, Ryabchun, Alexander, Domnguez, Maximilian Paradiz, Jan Buma, Wybren, Browne, Wesley R., Feringa, Ben L.

Issue&Volume: 2024-04-26

Abstract: Artificial molecular motors and machines constitute a critical element in the transition from individual molecular motion to the creation of collective dynamic molecular systems and responsive materials. The design of artificial light-driven molecular motors operating with high efficiency and selectivity constitutes an ongoing fundamental challenge. Here we present a highly versatile synthetic approach based on Rieche formylation that boosts the quantum yield of the forward photoisomerization reaction while reaching near-perfect selectivity in the steps involved in the unidirectional rotary cycle and drastically reducing competing photoreactions. This motor is readily accessible in its enantiopure form and operates with nearly quantitative photoconversions. It can easily be functionalized further and outperforms its direct predecessor as a reconfigurable chiral dopant in cholesteric liquid crystal materials.

DOI: 10.1038/s41557-024-01521-0

Source: https://www.nature.com/articles/s41557-024-01521-0