暨南大学李丹报道了模板引导硅微电机组装增强细胞操作。相关研究成果发表在2024年4月25日出版的《德国应用化学》。

光驱动微/纳米机器人（LMNRs）是一种微小的、不受束缚的机器，在精密医学、纳米制造和其他各种领域具有巨大潜力。然而，它们的实用性取决于开发将多功能、灵活的设计选项和精确的可控性相结合的光操纵策略。

该研究介绍了一种创新的方法，通过利用微/纳米电机作为基本构建块来构建微/纳米机器人。受硅金属绝缘体半导体太阳能电池原理的启发，研究人员设计了一种新型的光磁混合微电机。这些OHMs通过集成的磁性组件进行了巧妙的优化，从而实现了高效的光推进、精确的磁导航和可控组装的潜力。

OHMs的一个关键特征是，它们能够表现出受断裂表面和与环境相互作用影响的不同运动模式，从而简化沿“微型高速公路”（即预先设计的微通道）的货物运输。模板引导的组装策略进一步增强了它们的多功能性，有助于将这些微电机组装成功能性微机器人，包括各种配置，如“V形”、“N形”和3D结构微机器人。这些微型机器人的能力增强，突显了混合微型电机设计和组装所固有的创新潜力，为实现多组件微型机器人提供了基础平台。

该工作向即将推出的具有先进功能的微型机器人实体迈出了一步。

附：英文原文

Title: Template-guided Silicon Micromotor Assembly for Enhanced Cell Manipulation

Author: Yuxin Gao, Leyan Ou, Kunfeng Liu, Yuan Guo, Wanyuan Li, Ze Xiong, Changjin Wu, Jizhuang Wang, Jinyao Tang, Dan Li

Issue&Volume: 2024-04-25

Abstract: Light-driven micro/nanorobots (LMNRs) are tiny, untethered machines with great potential in fields like precision medicine, nano manufacturing, and various other domains. However, their practicality hinges on developing light-manipulation strategies that combine versatile functionalities, flexible design options, and precise controllability. Our study introduces an innovative approach to construct micro/nanorobots (MNRs) by utilizing micro/nanomotors as fundamental building blocks. Inspired by silicon Metal-Insulator-Semiconductor solar cell principles, we design a new type of optomagnetic hybrid micromotors (OHMs). These OHMs have been skillfully optimized with integrated magnetic constituent, resulting in efficient light propulsion, precise magnetic navigation, and the potential for controlled assembly. One of the key features of the OHMs is their ability to exhibit diverse motion modes influenced by fracture surfaces and interactions with the environment, streamlining cargo conveyance along "micro expressway" - the predesigned microchannels. Further enhancing their versatility, a template-guided assembly strategy facilitates the assembly of these micromotors into functional microrobots, encompassing various configurations such as "V-shaped", "N-shaped", and 3D structured microrobots. The heightened capabilities of these microrobots, underscore the innovative potential inherent in hybrid micromotor design and assembly, which provides a foundational platform for the realization of multi-component microrobots. Our work moves a step toward forthcoming microrobotic entities boasting advanced functionalities.

DOI: 10.1002/anie.202405895

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202405895