据介绍，监测体内平衡是获得治疗患者病理生理学见解的一个重要方面。准确、及时地评估深层组织中的稳态失调通常需要昂贵的成像技术或侵入性活检。
研究人员介绍了一种可生物吸收的形状自适应材料结构，该结构能够使用传统超声仪器实时监测深层组织稳态。分布在薄的pH响应水凝胶中的小型生物可吸收金属盘的集合，通过手术植入或注射器注射部署，允许基于超声的pH时空变化测量，用于胃肠道手术后吻合口泄漏的早期评估，并且它们在恢复期后的生物吸收消除了手术提取的需要。在小型和大型动物模型中的演示说明了这一材料监测小肠、胃和胰腺渗漏方面的能力。
附：英文原文
Title: Bioresorbable shape-adaptive structures for ultrasonic monitoring of deep-tissue homeostasis
Author: Jiaqi Liu, Naijia Liu, Yameng Xu, Mingzheng Wu, Haohui Zhang, Yue Wang, Ying Yan, Angela Hill, Ruihao Song, Zijie Xu, Minsu Park, Yunyun Wu, Joanna L. Ciatti, Jianyu Gu, Haiwen Luan, Yamin Zhang, Tianyu Yang, Hak-Young Ahn, Shupeng Li, Wilson Z. Ray, Colin K. Franz, Matthew R. MacEwan, Yonggang Huang, Chet W. Hammill, Heling Wang, John A. Rogers
Issue&Volume: 2024-03-08
Abstract: Monitoring homeostasis is an essential aspect of obtaining pathophysiological insights for treating patients. Accurate, timely assessments of homeostatic dysregulation in deep tissues typically require expensive imaging techniques or invasive biopsies. We introduce a bioresorbable shape-adaptive materials structure that enables real-time monitoring of deep-tissue homeostasis using conventional ultrasound instruments. Collections of small bioresorbable metal disks distributed within thin, pH-responsive hydrogels, deployed by surgical implantation or syringe injection, allow ultrasound-based measurements of spatiotemporal changes in pH for early assessments of anastomotic leaks after gastrointestinal surgeries, and their bioresorption after a recovery period eliminates the need for surgical extraction. Demonstrations in small and large animal models illustrate capabilities in monitoring leakage from the small intestine, the stomach, and the pancreas.
DOI: adk9880
Source: https://www.science.org/doi/10.1126/science.adk9880