瑞士洛桑联邦理工学院Dyson, Paul J.报道了串联催化使含氯废物成为氯化试剂。相关研究成果发表在2024年2月23日出版的《自然—化学》。

氯化化合物无处不在。然而，由于填埋和焚烧等常见处理方法的不适用性，含氯废物的积累对人类健康和环境产生了负面影响。

该文中，研究人员报告了一种可持续的方法，以含NaNO₃促进剂的铜和钯催化剂为基础，对含氯的碳氢化合物废物进行估价，包括固体（氯化聚合物）和液体（氯化溶剂）。在这个过程中，废物在N-导向芳烃的存在下被氧化以释放氯，从而提供有价值的芳基氯化物，如美国食品药品监督管理局批准的药物vismodegib。剩余的碳氢化合物组分被矿化以提供CO、CO₂和H₂O。

此外，所产生的CO和CO₂可以被进一步直接利用。因此，含氯的碳氢化合物废物，包括混合废物，可以作为氯化试剂，既不会产生危险的副产品，也不会涉及特殊的氯化试剂。这种串联催化方法代表了一种很有前途的方法，可以对各种各样的含氯碳氢化合物废物进行可行的管理。

附：英文原文

Title: Tandem catalysis enables chlorine-containing waste as chlorination reagents

Author: Liu, Mingyang, Wu, Xinbang, Dyson, Paul J.

Issue&Volume: 2024-02-23

Abstract: Chlorinated compounds are ubiquitous. However, accumulation of chlorine-containing waste has a negative impact on human health and the environment due to the inapplicability of common disposal methods, such as landfill and incineration. Here we report a sustainable approach to valorize chlorine-containing hydrocarbon waste, including solids (chlorinated polymers) and liquids (chlorinated solvents), based on copper and palladium catalysts with a NaNO3 promoter. In the process, waste is oxidized to release the chlorine in the presence of N-directing arenes to afford valuable aryl chlorides, such as the FDA-approved drug vismodegib. The remaining hydrocarbon component is mineralized to afford CO, CO2 and H2O. Moreover, the CO and CO2 generated could be further utilized directly. Thus, chlorine-containing hydrocarbon waste, including mixed waste, can serve as chlorination reagents that neither generate hazardous by-products nor involve specialty chlorination reagents. This tandem catalytic approach represents a promising method for the viable management of a wide and diverse range of chlorine-containing hydrocarbon wastes.

DOI: 10.1038/s41557-024-01462-8

Source: https://www.nature.com/articles/s41557-024-01462-8