瑞士苏黎世联邦理工学院Christian Wolfrum等研究人员，合作揭示了与肥胖代谢健康相关的脂肪细胞群体。这一研究成果于2024年12月17日在线发表在国际学术期刊《细胞—代谢》上。

研究人员生成了代谢健康和代谢不健康肥胖个体的，皮下和内脏脂肪组织（AT）的综合细胞图谱。通过结合单细胞核RNA测序数据、大规模转录组学数据和临床参数，研究人员发现间皮细胞、脂肪细胞和脂肪前体细胞与代谢疾病的关联最强。

此外，研究人员揭示了特定细胞的转录程序，如间皮细胞向间充质表型的转变，这些程序在将肥胖与代谢疾病解耦中起到了重要作用。

总的来说，这些发现通过揭示临床终点的生物学驱动因素，为深入了解肥胖与代谢疾病的关系提供了宝贵的见解。

据悉，尽管肥胖个体的代谢表型差异较大，精准医学仍未被视为肥胖治疗的标准方法。AT功能障碍是影响代谢性疾病风险变异性的重要因素之一，但关于不同细胞群体、细胞类型特异性转录程序，与疾病严重性之间的关联了解较少。

附：英文原文

Title: Unveiling adipose populations linked to metabolic health in obesity

Author: Isabel Reinisch, Adhideb Ghosh, Falko Noé, Wenfei Sun, Hua Dong, Peter Leary, Arne Dietrich, Anne Hoffmann, Matthias Blüher, Christian Wolfrum

Issue&Volume: 2024-12-17

Abstract: Precision medicine is still not considered as a standard of care in obesity treatment, despite a large heterogeneity in the metabolic phenotype of individuals with obesity. One of the strongest factors influencing the variability in metabolic disease risk is adipose tissue (AT) dysfunction; however, there is little understanding of the link between distinct cell populations, cell-type-specific transcriptional programs, and disease severity. Here, we generated a comprehensive cellular map of subcutaneous and visceral AT of individuals with metabolically healthy and unhealthy obesity. By combining single-nucleus RNA-sequencing data with bulk transcriptomics and clinical parameters, we identified that mesothelial cells, adipocytes, and adipocyte-progenitor cells exhibit the strongest correlation with metabolic disease. Furthermore, we uncovered cell-specific transcriptional programs, such as the transitioning of mesothelial cells to a mesenchymal phenotype, that are involved in uncoupling obesity from metabolic disease. Together, these findings provide valuable insights by revealing biological drivers of clinical endpoints.

DOI: 10.1016/j.cmet.2024.11.006

Source: https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00452-2