浙江大学田良飞团队报道了以凝聚体为基础的区隔系统中脂质囊泡的自发出现。相关研究成果发表在2024年12月10日出版的《德国应用化学》。

在没有进化生物机制的情况下，脂质囊泡的自发出现是自下而上合成生物学的一大挑战。

研究发现凝聚层微滴可以创造一个分隔的环境，丰富脂质分子并促进其自发组装成脂质囊泡。这些囊泡可以在非平衡条件下以连续过程从凝聚层微滴中逃逸，类似于类似于“原始酶”工厂装配线的恒定生产过程。

这些发现大大扩展了人们对脂质分子和凝聚层微滴之间复杂相互作用的理解，揭示了细胞系统的出现，并为地球上生命发展所需的条件提供了新的视角。

附：英文原文

Title: Spontaneous Emergence of Lipid Vesicles in a Coacervate-Based Compartmentalized System

Author: Liangfei Tian, Chengying Yin, Xinran Yu, Baohu Wu

Issue&Volume: 2024-12-10

Abstract: The spontaneous emergence of lipid vesicles in the absence of evolved biological machinery represents a major challenge for bottom-up synthetic biology. We show that coacervate microdroplets could create a compartmentalized environment that enriches lipid molecules and facilitates their spontaneous assembly into lipid vesicles. These vesicles can escape from the coacervate microdroplets in a continuous process under non-equilibrium conditions, resembling a constant production process akin to a "primitive enzyme" factory assembly line. These findings significantly extend our understanding of the intricate interaction between lipid molecules and coacervate microdroplets, shedding light on the emergence of cellular systems and offering a new perspective on the conditions necessary for the development of life on Earth.

DOI: 10.1002/anie.202414372

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202414372