美国耶鲁大学Nicholas A. Christakis等合作发现，孤立村庄社会网络共享肠道微生物群菌株。该研究于2024年11月20日发表于国际一流学术期刊《自然》杂志上。

据介绍，当人类聚集到面对面的社会网络中时，他们创造了一个扩展的社会环境，允许接触他人的微生物组，从而在个体和群体水平上塑造微生物组的组成和多样性。

研究人员对洪都拉斯18个孤立村庄的1787名成年人，进行了全面的社会网络测绘和详细的微生物组测序数据，以研究网络结构与肠道微生物组组成之间的关系。利用物种水平和菌株水平的数据，研究人员表明微生物共享发生在许多关系类型之间，特别是包括非家族和非家庭关系。

此外，菌株共享延伸到二级社会关系，表明一个人的更广泛的网络的相关性。研究人员还观察到，社会中心的人比社会边缘的人在微生物上与整个村庄更相似。

在重新测量微生物组的301人中，后续2年多后，研究人员观察到，有联系的村民与其他类似的没有联系的村民在菌株共享方面有更大的趋同。在村庄社交网络中，物种和菌株的聚集发生在聚集的人群中，这意味着社会网络提供了社会生态位，微生物组生物学和表型影响在其中得到体现。

附：英文原文

Title: Gut microbiome strain-sharing within isolated village social networks

Author: Beghini, Francesco, Pullman, Jackson, Alexander, Marcus, Shridhar, Shivkumar Vishnempet, Prinster, Drew, Singh, Adarsh, Matute Jurez, Rigoberto, Airoldi, Edoardo M., Brito, Ilana L., Christakis, Nicholas A.

Issue&Volume: 2024-11-20

Abstract: When humans assemble into face-to-face social networks, they create an extended social environment that permits exposure to the microbiome of others, thereby shaping the composition and diversity of the microbiome at individual and population levels1,2,3,4,5,6. Here we use comprehensive social network mapping and detailed microbiome sequencing data in 1,787 adults within 18 isolated villages in Honduras7 to investigate the relationship between network structure and gut microbiome composition. Using both species-level and strain-level data, we show that microbial sharing occurs between many relationship types, notably including non-familial and non-household connections. Furthermore, strain-sharing extends to second-degree social connections, suggesting the relevance of a person’s broader network. We also observe that socially central people are more microbially similar to the overall village than socially peripheral people. Among 301 people whose microbiome was re-measured 2years later, we observe greater convergence in strain-sharing in connected versus otherwise similar unconnected co-villagers. Clusters of species and strains occur within clusters of people in village social networks, meaning that social networks provide the social niches within which microbiome biology and phenotypic impact are manifested.

DOI: 10.1038/s41586-024-08222-1

Source: https://www.nature.com/articles/s41586-024-08222-1