美国范德比特大学André M. Bastos研究组，揭示了灵长类动物皮层中普遍存在的局部场电位(LFPs)功率的光谱层次基序。相关论文于2024年1月18日发表于国际顶尖学术期刊《自然—神经科学》杂志上。

他们报告了LFP功率中的这样一个基序。利用层流探针，他们记录了5只猕猴的14个皮层区域的LFP。记录的层状位置在组织学上通过电解病变确定。在所有区域中，他们发现了一个普遍存在的谱层流基序，其特征是第2/3层高频功率峰值从深到浅的梯度增加，第5/6层α-β功率峰值从浅到深的梯度增加。

来自其他物种的层流记录表明，光谱层流模式在灵长类动物(猕猴、狨猴和人类)中高度保留，但在小鼠中差异更大。他们的结果表明存在一种基于层和基于频率的皮质计算机制。

据悉，哺乳动物的大脑皮层在解剖学上被组织成六层基序。目前尚不清楚皮层中是否存在相应的神经元活动模式的层流基序。

附：英文原文

Title: A ubiquitous spectrolaminar motif of local field potential power across the primate cortex

Author: Mendoza-Halliday, Diego, Major, Alex James, Lee, Noah, Lichtenfeld, Maxwell J., Carlson, Brock, Mitchell, Blake, Meng, Patrick D., Xiong, Yihan (Sophy), Westerberg, Jacob A., Jia, Xiaoxuan, Johnston, Kevin D., Selvanayagam, Janahan, Everling, Stefan, Maier, Alexander, Desimone, Robert, Miller, Earl K., Bastos, Andr M.

Issue&Volume: 2024-01-18

Abstract: The mammalian cerebral cortex is anatomically organized into a six-layer motif. It is currently unknown whether a corresponding laminar motif of neuronal activity patterns exists across the cortex. Here we report such a motif in the power of local field potentials (LFPs). Using laminar probes, we recorded LFPs from 14 cortical areas across the cortical hierarchy in five macaque monkeys. The laminar locations of recordings were histologically identified by electrolytic lesions. Across all areas, we found a ubiquitous spectrolaminar pattern characterized by an increasing deep-to-superficial layer gradient of high-frequency power peaking in layers 2/3 and an increasing superficial-to-deep gradient of alpha-beta power peaking in layers 5/6. Laminar recordings from additional species showed that the spectrolaminar pattern is highly preserved among primates—macaque, marmoset and human—but more dissimilar in mouse. Our results suggest the existence of a canonical layer-based and frequency-based mechanism for cortical computation.

DOI: 10.1038/s41593-023-01554-7

Source: https://www.nature.com/articles/s41593-023-01554-7