法国索邦大学Wolf H. Fridman等研究人员总结瘤内的免疫循环。相关论文于近日在线发表在《免疫》杂志上。

研究人员回顾了三级淋巴结构（TLS）在T细胞和B细胞免疫力生成过程中的作用，重点关注B细胞完全成熟后产生浆细胞（PC）的影响，浆细胞可产生高亲和力IgG和IgA抗体。在这种情况下，研究人员认为与肿瘤细胞结合的抗体会诱导巨噬细胞或自然杀伤（NK）细胞凋亡。随后，释放的抗原-抗体复合物被树突状细胞（DC）内化和处理，扩大了向T细胞的抗原呈递。

免疫复合物还可能被TLS中的滤泡DC（FDC）固定，从而增强记忆性B细胞反应。这种放大循环形成了一种瘤内免疫循环，即使在突变负荷较低的癌症中也能提高肿瘤对免疫疗法的敏感性。

据悉，引流淋巴结中产生的抗肿瘤免疫被称为癌症免疫循环。越来越多的证据表明，在慢性炎症的背景下，肿瘤部位会出现这种循环。

附：英文原文

Title: Tertiary lymphoid structures and B cells: An intratumoral immunity cycle

Author: Wolf H. Fridman, Maxime Meylan, Guilhem Pupier, Anne Calvez, Isaas Hernandez, Catherine Sautès-Fridman

Issue&Volume:

Abstract: The generation of anti-tumor immunity in the draining lymph nodes is known as thecancer immunity cycle. Accumulating evidence supports the occurrence of such a cycleat tumor sites in the context of chronic inflammation. Here, we review the role oftertiary lymphoid structures (TLS) in the generation of T and B cell immunities, focusingon the impact of B cells that undergo full maturation, resulting in the generationof plasma cells (PCs) producing high-affinity IgG and IgA antibodies. In this context,we propose that antibodies binding to tumor cells induce macrophage or natural killer(NK)-cell-dependent apoptosis. Subsequently, released antigen-antibody complexes areinternalized and processed by dendritic cells (DCs), amplifying antigen presentationto T cells. Immune complexes may also be fixed by follicular DCs (FDCs) in TLS, therebyincreasing memory B cell responses. This amplification loop creates an intra-tumoralimmunity cycle, capable of increasing sensitivity of tumors to immunotherapy evenin cancers with low mutational burden.

DOI: 10.1016/j.immuni.2023.08.009

Source: https://www.cell.com/immunity/fulltext/S1074-7613(23)00365-5