英国威康桑格研究所Muzlifah Haniffa、Sarah A. Teichmann和英国威康- MRC剑桥干细胞研究所Berthold Göttgens研究组合作绘制卵黄囊(YS)细胞图谱，揭示了人类早期发育过程中的多器官功能。这一研究成果发表在2023年8月18日出版的国际学术期刊《科学》上。
他们通过整合单细胞蛋白和基因表达数据，建立了一个全面的人类YS多组参考资料，从受孕后3至8周。除了公认的造血功能外，他们还强调了其在代谢、凝血、血管发育和造血调节中的作用。他们重建了造血内皮中YS造血干细胞和祖细胞的出现和衰退，并揭示了YS特异性的巨噬细胞加速产生的途径。随着胚胎内器官的发育，YS的多器官功能被取代，随着怀孕的进行，影响了多方面的重要功能。
据了解，YS确保向发育中的胚胎提供营养支持和氧气，但在人类中仍然不明确。
附：英文原文
Title: Yolk sac cell atlas reveals multiorgan functions during human early development
Author: Issac Goh, Rachel A. Botting, Antony Rose, Simone Webb, Justin Engelbert, Yorick Gitton, Emily Stephenson, Mariana Quiroga Londoo, Michael Mather, Nicole Mende, Ivan Imaz-Rosshandler, Lu Yang, Dave Horsfall, Daniela Basurto-Lozada, Nana-Jane Chipampe, Victoria Rook, Jimmy Tsz Hang Lee, Mai-Linh Ton, Daniel Keitley, Pavel Mazin, M. S. Vijayabaskar, Rebecca Hannah, Laure Gambardella, Kile Green, Stephane Ballereau, Megumi Inoue, Elizabeth Tuck, Valentina Lorenzi, Kwasi Kwakwa, Clara Alsinet, Bayanne Olabi, Mohi Miah, Chloe Admane, Dorin-Mirel Popescu, Meghan Acres, David Dixon, Thomas Ness, Rowen Coulthard, Steven Lisgo, Deborah J. Henderson, Emma Dann, Chenqu Suo, Sarah J. Kinston, Jong-eun Park, Krzysztof Polanski, John Marioni, Stijn van Dongen, Kerstin B. Meyer, Marella de Bruijn, James Palis, Sam Behjati, Elisa Laurenti, Nicola K. Wilson, Roser Vento-Tormo, Alain Chédotal, Omer Bayraktar, Irene Roberts, Laura Jardine, Berthold Gttgens, Sarah A. Teichmann, Muzlifah Haniffa
Issue&Volume: 2023-08-18
Abstract: The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconception weeks by integrating single-cell protein and gene expression data. Beyond its recognized role as a site of hematopoiesis, we highlight roles in metabolism, coagulation, vascular development, and hematopoietic regulation. We reconstructed the emergence and decline of YS hematopoietic stem and progenitor cells from hemogenic endothelium and revealed a YS-specific accelerated route to macrophage production that seeds developing organs. The multiorgan functions of the YS are superseded as intraembryonic organs develop, effecting a multifaceted relay of vital functions as pregnancy proceeds.
DOI: add7564
Source: https://www.science.org/doi/full/10.1126/science.add7564