超小型铸造金属纳米团簇(NCs,<3nm)由于其原子精确的尺寸和工程化的物理化学性质,已成为一类新型的治疗探针。基于金属NC的治疗探针的设计和应用的快速进步是通过金属NCs的原子级工程实现的。
该文探讨了(i)金属NCs的功能是如何被设计用于治疗应用的,(ii)基于金属NC的治疗探针是如何设计的,其物理化学性质如何影响治疗性能,以及(iii)金属NCs是如何被用于诊断和治疗各种疾病的。研究人员首先从生物相容性和肿瘤靶向性的角度总结了金属纳米晶体在治疗应用中的定制特性。重点讨论了金属NCs在生物成像导向疾病诊断、光诱导疾病治疗、纳米医学、药物递送和光学尿液分析中的治疗应用。最后,展望了用于治疗应用的金属纳米晶体未来发展的挑战和机遇。
附:英文原文
Title: Ultrasmall Coinage Metal Nanoclusters as Promising Theranostic Probes for Biomedical Applications
Author: Ge Yang, Ziping Wang, Fanglin Du, Fuyi Jiang, Xun Yuan, Jackie Y. Ying
Issue&Volume: May 18, 2023
Abstract: Ultrasmall coinage metal nanoclusters (NCs, <3 nm) have emerged as a novel class of theranostic probes due to their atomically precise size and engineered physicochemical properties. The rapid advances in the design and applications of metal NC-based theranostic probes are made possible by the atomic-level engineering of metal NCs. This Perspective article examines (i) how the functions of metal NCs are engineered for theranostic applications, (ii) how a metal NC-based theranostic probe is designed and how its physicochemical properties affect the theranostic performance, and (iii) how metal NCs are used to diagnose and treat various diseases. We first summarize the tailored properties of metal NCs for theranostic applications in terms of biocompatibility and tumor targeting. We focus our discussion on the theranostic applications of metal NCs in bioimaging-directed disease diagnosis, photoinduced disease therapy, nanomedicine, drug delivery, and optical urinalysis. Lastly, an outlook on the challenges and opportunities in the future development of metal NCs for theranostic applications is provided.
DOI: 10.1021/jacs.3c02880
Source: https://pubs.acs.org/doi/10.1021/jacs.3c02880
JACS:《美国化学会志》,创刊于1879年。隶属于美国化学会,最新IF:16.383
官方网址:https://pubs.acs.org/journal/jacsat
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