日本大阪大学Eiji Hara、Shimpei Kawamoto课题组取得一项新突破。他们发现细菌诱导的B细胞衰老促进与年龄相关肠道微生物群变化。该研究于2023年5月11日发表于国际学术期刊《自然—细胞生物学》杂志。

研究表明持续存在的共生细菌会逐渐诱导肠道生发中心B细胞的衰老。重要的是，这减少了靶向肠道细菌免疫球蛋白A（IgA）抗体的产生和多样性，从而改变了老年小鼠肠道微生物群的组成。这些结果揭示了肠道微生物群和细胞衰老之间存在IgA介导的串扰，从而扩展了人们对肠道微生物群随年龄变化机制的理解，并为控制它们提供了可能。

研究人员表示，人们渴望阐明衰老的机制并确定控制衰老的方法。最近研究表明，衰老细胞积累和肠道微生物群组成变化这两个与衰老相关的因素在衰老中起关键作用。然而，人们对这些现象的发生机制以及其在衰老过程中的关联知之甚少。

附：英文原文

Title: Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota

Author: Kawamoto, Shimpei, Uemura, Ken, Hori, Nozomi, Takayasu, Lena, Konishi, Yusuke, Katoh, Kazutaka, Matsumoto, Tomonori, Suzuki, Masae, Sakai, Yusuke, Matsudaira, Tatsuyuki, Adachi, Takahiro, Ohtani, Naoko, Standley, Daron M., Suda, Wataru, Fukuda, Shinji, Hara, Eiji

Issue&Volume: 2023-05-11

Abstract: The elucidation of the mechanisms of ageing and the identification of methods to control it have long been anticipated. Recently, two factors associated with ageing—the accumulation of senescent cells and the change in the composition of gut microbiota—have been shown to play key roles in ageing. However, little is known about how these phenomena occur and are related during ageing. Here we show that the persistent presence of commensal bacteria gradually induces cellular senescence in gut germinal centre B cells. Importantly, this reduces both the production and diversity of immunoglobulin A (IgA) antibodies that target gut bacteria, thereby changing the composition of gut microbiota in aged mice. These results have revealed the existence of IgA-mediated crosstalk between the gut microbiota and cellular senescence and thus extend our understanding of the mechanism of gut microbiota changes with age, opening up possibilities for their control.

DOI: 10.1038/s41556-023-01145-5

Source: https://www.nature.com/articles/s41556-023-01145-5