近日，英国弗朗西斯·克里克研究所Markus Ralser等研究人员合作发现，细胞-细胞代谢物交换创造一个有利于生存的代谢环境来延长寿命。2023年1月5日出版的《细胞》杂志发表了这项成果。

Title: Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan

Author: Clara Correia-Melo, Stephan Kamrad, Roland Tenglics, Christoph B. Messner, Pauline Trebulle, StJohn Townsend, Sreejith Jayasree Varma, Anja Freiwald, Benjamin M. Heineike, Kate Campbell, Lucía Herrera-Dominguez, Simran Kaur Aulakh, Lukasz Szyrwiel, Jason S.L. Yu, Aleksej Zelezniak, Vadim Demichev, Michael Mülleder, Balázs Papp, Mohammad Tauqeer Alam, Markus Ralser

Issue&Volume: 2023/01/05

Abstract: Metabolism is deeply intertwined with aging. Effects of metabolic interventions on aging have been explained with intracellular metabolism, growth control, and signaling. Studying chronological aging in yeast, we reveal a so far overlooked metabolic property that influences aging via the exchange of metabolites. We observed that metabolites exported by young cells are re-imported by chronologically aging cells, resulting in cross-generational metabolic interactions. Then, we used self-establishing metabolically cooperating communities (SeMeCo) as a tool to increase metabolite exchange and observed significant lifespan extensions. The longevity of the SeMeCo was attributable to metabolic reconfigurations in methionine consumer cells. These obtained a more glycolytic metabolism and increased the export of protective metabolites that in turn extended the lifespan of cells that supplied them with methionine. Our results establish metabolite exchange interactions as a determinant of cellular aging and show that metabolically cooperating cells can shape the metabolic environment to extend their lifespan.

DOI: 10.1016/j.cell.2022.12.007

Source: https://www.cell.com/cell/fulltext/S0092-8674(22)01520-3