国家纳米科学中心陈春英团队开发出了钴-单原子纳米酶协同纳米催化化疗的肿瘤-微环境-响应级联反应。相关研究成果发表在2022年8月16日出版的《德国应用化学》。

基于纳米酶在肿瘤微环境（TME）中引发活性氧（ROS）产生的纳米催化治疗已显示出在肿瘤治疗中的潜力，但纳米酶仍面临着活性和特异性的挑战，从而影响治疗效果。

该文中，研究人员开发了一种创新策略，使用单原子纳米酶在TME中启动级联酶反应，用于肿瘤特异性治疗。钴（Co）-单原子纳米酶，在N-掺杂多孔碳上具有Co-N配位（Co-SAs@NC），表现出分解细胞内源性H₂O₂以产生O₂的过氧化氢酶样活性，以及随后将O₂转化为细胞毒性超氧自由基以有效杀死肿瘤细胞的氧化酶样活性。

通过与阿霉素结合，该疗法在体内实现了显著增强的抗肿瘤效果。研究结果表明，级联TME特异性催化疗法结合化疗是一种有前途的用于高效效肿瘤治疗的策略。

附：英文原文

Title: Tumor-Microenvironment-Responsive Cascade Reactions by a Cobalt-Single-Atom Nanozyme for Synergistic Nanocatalytic Chemotherapy

Author: Shuangfei Cai, Jiaming Liu, Jianwei Ding, Zhao Fu, Haolin Li, Youlin Xiong, Zheng Lian, Rong Yang, Chunying Chen

Issue&Volume: 2022-08-16

Abstract: Nanocatalytic therapy, based on the nanozyme-triggered production of reactive oxygen species (ROS) in tumor microenvironment (TME), has demonstrated potential in tumor therapy, but nanozymes still face challenges of activity and specificity that compromise the therapeutic efficacy. Herein, we develop an innovative strategy using a single-atom nanozyme to initiate cascade enzymatic reactions in TME for tumor-specific treatment. The cobalt (Co)-single-atom nanozyme, with Co-  N  coordination on  N  -doped porous carbon (  Co-SAs@NC  ),  displays catalase-like activity that  decompose cellular endogenous H  2  O  2  to produce O  2  , and subsequent oxidase-like activity that converts O  2  into cytotoxic  superoxide radicals  to efficiently kill tumor cells. By incorporation with doxorubicin, the therapy achieves a significantly enhanced antitumor effect  in vivo  . Our findings show that cascade TME-specific catalytic therapy combining with chemotherapy is a promising strategy for efficient tumor therapy.

DOI: 10.1002/anie.202204502

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202204502