南方医科大学张惠杰团队比较了在减肥过程中限制热量摄入，伴或不伴时间限制饮食的效果。相关论文于2022年4月20日发表在《新英格兰医学杂志》上。

目前限制时间进食减肥的长期疗效和安全性尚不清楚。

研究组随机将139名肥胖患者在饮食上分为时间限制+热量限制组（仅在上午8:00到下午4:00之间进食）和每日热量限制组。在12个月的时间里，所有参与者都被要求遵循热量限制饮食，其中男性每天1500-1800千卡，女性每天1200-1500千卡。主要结局是两组之间体重变化与基线相比的差异；次要结局包括腰围、体重指数（BMI）、体脂量的变化以及代谢危险因素的变化。

在接受随机分组的139名参与者中，118名（84.9%）完成了12个月的随访。时间限制组12个月时与基线检查相比平均体重减轻8.0千克，每日热量限制组平均减轻6.3千克。在12个月的评估中，两组的体重变化没有显著差异（净差异为−1.8公斤）。腰围、BMI、体脂、瘦体量、血压和代谢危险因素的分析结果与主要结局一致。此外，两组之间的不良事件数量没有实质性差异。

研究结果表明，对于肥胖患者，在减轻体重、体脂或代谢危险因素方面，限时饮食方案并不比每日热量限制更有益。

附：英文原文

Title: Calorie Restriction with or without Time-Restricted Eating in Weight Loss

Author: Deying Liu, M.D.,, Yan Huang, M.S.,, Chensihan Huang, M.D.,, Shunyu Yang, M.D.,, Xueyun Wei, M.D.,, Peizhen Zhang, M.D.,, Dan Guo, M.D.,, Jiayang Lin, M.D.,, Bingyan Xu, M.D.,, Changwei Li, Ph.D.,, Hua He, Ph.D.,, Jiang He, M.D., Ph.D.,, Shiqun Liu, M.D.,, Linna Shi, M.D.,, Yaoming Xue, M.D.,, and Huijie Zhang, M.D., Ph.D.

Issue&Volume: 2022-04-20

Abstract:

Background

The long-term efficacy and safety of time-restricted eating for weight loss are not clear.

Methods

We randomly assigned 139 patients with obesity to time-restricted eating (eating only between 8:00 a.m. and 4:00 p.m.) with calorie restriction or daily calorie restriction alone. For 12 months, all the participants were instructed to follow a calorie-restricted diet that consisted of 1500 to 1800 kcal per day for men and 1200 to 1500 kcal per day for women. The primary outcome was the difference between the two groups in the change from baseline in body weight; secondary outcomes included changes in waist circumference, body-mass index (BMI), amount of body fat, and measures of metabolic risk factors.

Results

Of the total 139 participants who underwent randomization, 118 (84.9%) completed the 12-month follow-up visit. The mean weight loss from baseline at 12 months was 8.0 kg (95% confidence interval [CI], 9.6 to 6.4) in the time-restriction group and 6.3 kg (95% CI, 7.8 to 4.7) in the daily-calorie-restriction group. Changes in weight were not significantly different in the two groups at the 12-month assessment (net difference, 1.8 kg; 95% CI, 4.0 to 0.4; P=0.11). Results of analyses of waist circumferences, BMI, body fat, body lean mass, blood pressure, and metabolic risk factors were consistent with the results of the primary outcome. In addition, there were no substantial differences between the groups in the numbers of adverse events.

Conclusions

Among patients with obesity, a regimen of time-restricted eating was not more beneficial with regard to reduction in body weight, body fat, or metabolic risk factors than daily calorie restriction.

DOI: 10.1056/NEJMoa2114833

Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2114833