在该文中,研究人员阐明了pyrrocidine B (3)和GKK1032 A2 (4)的生物合成途径。两种假设中的小蛋白——一个氧化还原酶和一个脂质运载蛋白样蛋白——在环番的氧化性环化中协同作用。而另一种假设中的蛋白质则在pyrrocidine合成路线中催化特异性的exo-环加成,以形成顺式并环的十氢化芴。
据介绍,Hirsutellone是一类真菌天然产物,其中含有与十氢化芴环相连接的大环对位环番。
附:英文原文
Title: Biosynthesis of para-Cyclophane-Containing Hirsutellone Family of Fungal Natural Products
Author: Masao Ohashi, Thomas B. Kakule, Man-Cheng Tang, Cooper S. Jamieson, Mengting Liu, Yi-Lei Zhao, Kendall N. Houk, Yi Tang
Issue&Volume: April 9, 2021
Abstract: Hirsutellones are fungal natural products containing a macrocyclic para-cyclophane connected to a decahydrofluorene ring system. We have elucidated the biosynthetic pathway for pyrrocidine B (3) and GKK1032 A2 (4). Two small hypothetical proteins, an oxidoreductase and a lipocalin-like protein, function cooperatively in the oxidative cyclization of the cyclophane, while an additional hypothetical protein in the pyrrocidine pathway catalyzes the exo-specific cycloaddition to form the cis-fused decahydrofluorene.
DOI: 10.1021/jacs.1c00098
Source: https://pubs.acs.org/doi/10.1021/jacs.1c00098
JACS:《美国化学会志》,创刊于1879年。隶属于美国化学会,最新IF:14.612
官方网址:https://pubs.acs.org/journal/jacsat
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