美国波士顿大学 Wilson W. Wong和哈佛大学James J. Collins研究组合作发表综述。他们介绍了合成生物学在临床的应用：工程疫苗、诊断和治疗。该综述于2021年2月18日发表在《细胞》杂志上。

在本综述中，研究人员重点介绍了合成生物学在疫苗研发、分子诊断和细胞疗法中的应用，重点介绍了已批准用于临床或正处在临床试验的技术。 最后，研究人员强调注意合成生物学的最新创新，这些创新可能会对生物医学的未来应用产生重大影响。

据悉，合成生物学是一门设计驱动的学科，其重点是通过发现、表征和重新利用分子结构来产生新颖的生物学功能。针对关键生物医学问题的几种合成生物学解决方案正处于广泛应用的边缘，并且该领域处在迅速成熟阶段。

附：英文原文

Title: Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics

Author: Xiao Tan, Justin H. Letendre, James J. Collins, Wilson W. Wong

Issue&Volume: 2021/02/18

Abstract: Synthetic biology is a design-driven discipline centered on engineering novel biological functions through the discovery, characterization, and repurposing of molecular parts. Several synthetic biological solutions to critical biomedical problems are on the verge of widespread adoption and demonstrate the burgeoning maturation of the field. Here, we highlight applications of synthetic biology in vaccine development, molecular diagnostics, and cell-based therapeutics, emphasizing technologies approved for clinical use or in active clinical trials. We conclude by drawing attention to recent innovations in synthetic biology that are likely to have a significant impact on future applications in biomedicine.

DOI: 10.1016/j.cell.2021.01.017

Source: https://www.cell.com/cell/fulltext/S0092-8674(21)00060-X