直播时间：2025年8月15日（周五）20:00-21:30

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北京时间2025年8月15日晚八点，iCANX Talks 第240期邀请到了斯坦福大学副教授Sindy KY Tang担任主讲嘉宾，香港科技大学助理教授刘佳琪、深势科技生态系统运营负责人程远方、北京大学助理教授韩梦迪担任研讨嘉宾，北京大学教授张海霞担任主持人。

这将是一场汇聚顶尖学者的盛会，共同探讨前沿科技与学术挑战！更多精彩，敬请期待！

【嘉宾介绍】

Sindy KY Tang‍

斯坦福大学

Micro-surgical tools for dissecting cells and tissues

【Abstract】

Wound healing is an essential biological process for maintaining homeostasis and, ultimately, for survival. We investigate the mechanisms underlying extreme wound healing in Stentor coeruleus, a single-celled organism, capable of recovering from drastic membrane wounds exceeding half of the cell surface. This talk focuses on our recent effort on developing a microfluidic platform for the manipulation and reproducible wounding of the cell. We demonstrate a microfluidic "guillotine" for bisecting cells in a continuous flow, and a "SMORES" platform to immobilize the cells for laser ablation. We further discuss the extension of the tool for dissecting live tumors to generate organoids that preserve the tumor immune microenvironment for applications including the testing of immunotherapy on a chip.

伤口愈合是维持稳态乃至生存所必需的重要生物过程。我们研究了生物体“蓝色喇叭虫”（Stentor coeruleus）的极端伤口愈合机制；该单细胞生物能够在细胞膜受损面积超过细胞表面积一半的情况下完成自我修复。本次报告重点介绍我们近期在构建微流控平台方面的工作——该平台可用于对细胞进行精准操控及可重复的创伤实验。我们展示了一种微流控“断头台”，可在连续流中对细胞进行精准切割；以及一个名为“SMORES”的平台，可固定细胞并利用激光烧蚀实现创伤。我们还将讨论如何将该技术拓展至活体肿瘤的解剖，以生成保留肿瘤免疫微环境的类器官，并应用于芯片上的免疫疗法测试等场景。

【BIOGRAPHY】

Prof. Sindy KY Tang is the Kenneth and Barbara Oshman Faculty Scholar and Associate Professor of Mechanical Engineering and by courtesy of Bioengineering and Radiology (Precision Health and Integrated Diagnostics) at Stanford University. She received her Ph.D. from Harvard University in Engineering Sciences. The micro-nano-bio lab under the direction of Prof. Tang aims to develop innovative micro and nanoscale devices that enable precise manipulation, measurement, and recapitulation of biological systems, in order to understand the "rules of life" and accelerate precision medicine and material design for a future with better health and environmental sustainability. Prof. Tang’s work has been recognized by multiple awards including the NSF CAREER Award, and invited lecture at the Nobel Symposium on Microfluidics in Sweden. Website: http://web.stanford.edu/group/tanglab/

Sindy KY Tang 教授是 Kenneth & Barbara Oshman 学者、斯坦福大学机械工程系副教授，兼聘于生物工程系及放射学系（精准健康与综合诊断）。她于哈佛大学工程科学专业获博士学位。Tang 教授领导的微-纳-生物实验室致力于开发创新的微纳尺度器件，实现对生物系统的精准操控、测量与重构，以揭示“生命规律”，加速精准医疗与材料设计，共创更健康、可持续的未来。Tang 教授曾先后荣获 NSF CAREER 奖、瑞典诺贝尔微流控研讨会邀请报告等多项荣誉。实验室网站：http://web.stanford.edu/group/tanglab/