直播时间：2025年6月20日（周五）20:00-21:30

直播平台：

https://rmtzx.sciencenet.cn/app/kexuewang/liveShare/#/cathay?broadcastId=2f2750fa-a5e5-4e4a-80f0-8e5295754820

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北京时间2025年6月20日晚八点，iCANX Talks 第232期邀请到了韩国科学技术院（KAIST）副教授Hyunjoo Jenny Lee担任主讲嘉宾，韩国科学技术院（KAIST）副教授Chul Kim、韩国科学技术院（KAIST）副教授Miso Kim、北京大学教授张海霞作为研讨嘉宾，汉阳大学副教授Sangtae Kim担任主持人。

这将是一场汇聚顶尖学者的盛会，共同探讨前沿科技与学术挑战！更多精彩，敬请期待！

【嘉宾介绍】

Hyunjoo Jenny Lee

‍韩国科学技术院（KAIST）

Bi-directional Neural Interfaces: From Precision Monitoring to Ultrasound Neuromodulation

【Abstract】

Bidirectional brain-machine interfaces (BMIs) are poised to revolutionize our understanding and treatment of brain function by enabling both precise recording and targeted stimulation of neural activity. In this talk, I will present an integrated technological framework that spans from neural monitoring in complex biological models to non-invasive neuromodulation using ultrasound. We begin with recent advances in high-resolution, multimodal neural interfaces for in vivo applications and 3D organoid models, addressing limitations in spatial coverage, transparency, and biocompatibility. Through novel probe designs such as dual-sided and stretchable microelectrode arrays, we enable continuous, artifact-free observation of electrical and chemical signals at high fidelity. The second half of the talk introduces ultrasound as a next-generation neuromodulation modality. Unlike traditional electrical or magnetic stimulation, ultrasound offers a unique combination of deep tissue penetration, millimeter-scale focus ability, and wireless applicability. I will highlight our work on miniaturized capacitive micromachined ultrasound transducers (CMUTs), skull-compensated targeting strategies, and soft adhesive patches that support freely moving, chronic neuromodulation studies. Demonstrations in sleep modulation, memory consolidation, and inflammatory disease models illustrate the therapeutic potential of this platform. Ultimately, I will discuss the roadmap toward fully wearable, closed-loop “acoustoceutical” systems that combine soft electronics, precision ultrasound, and real-time feedback to unlock new frontiers in personalized neural therapeutics.

双向脑机接口（BMIs）有望通过实现对神经活动的精准记录和靶向刺激，彻底改变我们对大脑功能的理解和治疗方法。在本次演讲中，我将介绍一个综合技术框架，该框架涵盖了从复杂生物模型中的神经监测到使用超声进行非侵入性神经调控。我们从高分辨率、多模态神经接口的最新进展开始，这些接口适用于体内应用和三维类器官模型，解决了空间覆盖范围、透明性和生物相容性方面的限制。通过新型探针设计，例如双面和可拉伸的微电极阵列，我们能够以高保真度实现电和化学信号的连续、无伪影观测。演讲的后半部分将介绍超声作为一种下一代神经调控方式。与传统的电或磁刺激不同，超声具有独特的深度组织穿透能力、毫米级聚焦能力和无线适用性。我将重点介绍我们在微型化电容式微机电超声换能器（CMUTs）、头骨补偿靶向策略以及支持自由运动的慢性神经调控研究的软粘附贴片方面的工作。在睡眠调控、记忆巩固和炎症疾病模型中的演示展示了该平台的治疗潜力。最后，我将讨论实现完全可穿戴、闭环“声药”系统的路线图，该系统结合了软电子技术、精准超声和实时反馈，以开辟个性化神经治疗的新领域。

【BIOGRAPHY】

Hyunjoo Jenny Lee is an Associate Professor and KAIST Endowed Chair Professor in the School of Electrical Engineering at the Korea Advanced Institute of Science and Technology (KAIST). She received her B.S. and M.Eng. degrees in Electrical Engineering and Computer Science from the Massachusetts Institute of Technology (MIT) in 2004 and 2005, respectively, and her Ph.D. in Electrical Engineering from Stanford University in 2012. Her research focuses on MEMS sensors and actuators for biomedical applications, including neural interfaces, ultrasound transducers, epidermal electronics, and biosensors. She has authored over 50 journal and conference papers in these areas. She served as the General Co-Chair of the 2025 IEEE MEMS Conference in Kaohsiung, Taiwan. She is also an Associate Editor for Microsystems & Nanoengineering, IEEE Electron Device Letters, and IEEE Journal of Microelectromechanical Systems. She is a member of both the National Academy of Engineering of Korea and the Young Korean Academy of Science and Technology. Her honors include the Minister of Science and ICT Award (2022), the S-Oil Next-Generation Scientist Award (2022), the KAIST Technology Innovation Award (2021), and the World Economic Forum Young Scientist Award (2017).

Hyunjoo Jenny Lee现任韩国科学技术院（KAIST）电气工程学院副教授及KAIST特聘教授。她于2004年获得麻省理工学院（MIT）电气工程与计算机科学学士学位，2005年获得该校工程硕士学位（M.Eng.），并于2012年获得斯坦福大学电气工程博士学位。Hyunjoo Jenny Lee的研究聚焦于用于生物医学应用的微机电系统（MEMS）传感器与执行器，具体领域涵盖神经接口、超声换能器、表皮电子器件以及生物传感器。她在这些领域已发表超过50篇期刊及会议论文。李教授曾担任2025年IEEE MEMS会议（在中国台湾高雄举行）的共同主席，并担任《微系统与纳米工程》（Microsystems & Nanoengineering）、《IEEE电子器件快报》（IEEE Electron Device Letters）和《IEEE微机电系统杂志》（Journal of Microelectromechanical Systems）的副主编。她是韩国国家工程院和韩国青年科学技术院的成员。其重要荣誉包括2022年韩国科学技术信息通信部长奖、2022年S-Oil新一代科学家奖、2021年KAIST技术创新奖以及2017年世界经济论坛青年科学家奖。