人和小鼠免疫细胞脂质图谱揭示出铁中毒的易感性，这一成果由澳大利亚贝克心脏与糖尿病研究所Andrew J. Murphy团队经过不懈努力而取得。2024年4月8日出版的《自然-细胞生物学》杂志发表了这项成果。

研究人员利用基于质谱的靶向脂质组学，描述了人类和小鼠免疫细胞（www.cellularlipidatlas.com）的脂质图谱。利用这一资源，研究发现免疫细胞具有独特的脂质体特征，并且其活化、成熟和发育等过程会影响免疫细胞的脂质组成。为了证明这一资源在深入了解免疫细胞生物学方面的潜力，研究确定了细胞特异性脂质特征——含多不饱和脂肪酸的甘油磷脂（PUFA-PLs）丰度的差异——如何影响免疫细胞生物学。

首先，研究表明，PUFA-PL含量的差异是免疫细胞对铁变态反应不同敏感性的基础。其次，研究发现低PUFA-PL含量会促进活化中性粒细胞对铁中毒的抵抗力。总之，该研究表明，脂质结构是免疫细胞特性的一个决定性因素，细胞特异性脂质表型是免疫细胞生理学的基础。

据介绍，细胞脂质体由数千种独特的脂质组成。

附：英文原文

Title: A lipid atlas of human and mouse immune cells provides insights into ferroptosis susceptibility

Author: Morgan, Pooranee K., Pernes, Gerard, Huynh, Kevin, Giles, Corey, Paul, Sudip, Smith, Adam Alexander T., Mellett, Natalie A., Liang, Amy, van Buuren-Milne, Tilly, Veiga, Camilla Bertuzzo, Collins, Thomas J. C., Xu, Yangsong, Lee, Man K. S., De Silva, T. Michael, Meikle, Peter J., Lancaster, Graeme I., Murphy, Andrew J.

Issue&Volume: 2024-04-08

Abstract: The cellular lipidome comprises thousands of unique lipid species. Here, using mass spectrometry-based targeted lipidomics, we characterize the lipid landscape of human and mouse immune cells (www.cellularlipidatlas.com). Using this resource, we show that immune cells have unique lipidomic signatures and that processes such as activation, maturation and development impact immune cell lipid composition. To demonstrate the potential of this resource to provide insights into immune cell biology, we determine how a cell-specific lipid trait—differences in the abundance of polyunsaturated fatty acid-containing glycerophospholipids (PUFA-PLs)—influences immune cell biology. First, we show that differences in PUFA-PL content underpin the differential susceptibility of immune cells to ferroptosis. Second, we show that low PUFA-PL content promotes resistance to ferroptosis in activated neutrophils. In summary, we show that the lipid landscape is a defining feature of immune cell identity and that cell-specific lipid phenotypes underpin aspects of immune cell physiology.

DOI: 10.1038/s41556-024-01377-z

Source: https://www.nature.com/articles/s41556-024-01377-z