美国哥伦比亚大学Gwyneth M. Card等研究人员合作发现,突触梯度转换物体位置转换为行动。相关论文于2023年1月4日在线发表在《自然》杂志上。
Title: Synaptic gradients transform object location to action
Author: Dombrovski, Mark, Peek, Martin Y., Park, Jin-Yong, Vaccari, Andrea, Sumathipala, Marissa, Morrow, Carmen, Breads, Patrick, Zhao, Arthur, Kurmangaliyev, Yerbol Z., Sanfilippo, Piero, Rehan, Aadil, Polsky, Jason, Alghailani, Shada, Tenshaw, Emily, Namiki, Shigehiro, Zipursky, S. Lawrence, Card, Gwyneth M.
Issue&Volume: 2023-01-04
Abstract: To survive, animals must convert sensory information into appropriate behaviours1,2. Vision is a common sense for locating ethologically relevant stimuli and guiding motor responses3,4,5. How circuitry converts object location in retinal coordinates to movement direction in body coordinates remains largely unknown. Here we show through behaviour, physiology, anatomy and connectomics in Drosophila that visuomotor transformation occurs by conversion of topographic maps formed by the dendrites of feature-detecting visual projection neurons (VPNs)6,7 into synaptic weight gradients of VPN outputs onto central brain neurons. We demonstrate how this gradient motif transforms the anteroposterior location of a visual looming stimulus into the fly’s directional escape. Specifically, we discover that two neurons postsynaptic to a looming-responsive VPN type promote opposite takeoff directions. Opposite synaptic weight gradients onto these neurons from looming VPNs in different visual field regions convert localized looming threats into correctly oriented escapes. For a second looming-responsive VPN type, we demonstrate graded responses along the dorsoventral axis. We show that this synaptic gradient motif generalizes across all 20 primary VPN cell types and most often arises without VPN axon topography. Synaptic gradients may thus be a general mechanism for conveying spatial features of sensory information into directed motor outputs.
DOI: 10.1038/s41586-022-05562-8
Source: https://www.nature.com/articles/s41586-022-05562-8
Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:69.504
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html