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数字远程监控加常规护理与常规护理的比较
作者：小柯机器人 发布时间：2022/4/26 13:12:00

法国Olivier Mir等研究人员完成在接受口服抗癌药治疗的患者中，数字远程监控加常规护理与常规护理的比较。相关论文于2022年4月25日在线发表于国际学术期刊《自然—医学》。

研究人员报告了一项3期试验（CAPRI，NCT02828462）的结果，以评估护士引导的计划对转移性癌症患者治疗的影响。接受经批准的口服抗癌药患者被随机（1:1）接受干预，在常规护理的基础上结合护士导航员领导的随访系统和门户网站-智能手机应用程序，或由治疗的肿瘤医生决定接受常规症状监测，持续时间为6个月。主要目标包括优化治疗剂量。次要目标是≥3级的毒性、病人的经验、住院率和住院时间、反应和生存，以及生活质量。
 
在559名可评估的患者中，实验组的相对剂量强度更高（93.4%对89.4%，P=0.04）。干预措施改善了患者的体验（患者慢性病护理评估得分，2.94对2.67，P=0.01），减少了住院天数（2.82对4.44天，P=0.02），并减少了治疗相关的≥3级毒性反应（27.6%对36.9%，P=0.02）。这些发现表明，通过远程监测症状和治疗，以病人为中心的护理可能会改善病人的结局和体验。
 
据悉，对接受口服抗癌药的癌症患者进行个性化护理的策略提供了改善治疗依从性和患者护理的机会。然而，数字远程监控系统在这种情况下的影响还没有得到评估。
 
附：英文原文

Title: Digital remote monitoring plus usual care versus usual care in patients treated with oral anticancer agents: the randomized phase 3 CAPRI trial

Author: Mir, Olivier, Ferrua, Marie, Fourcade, Aude, Mathivon, Delphine, Duflot-Boukobza, Adeline, Dumont, Sarah, Baudin, Eric, Delaloge, Suzette, Malka, David, Albiges, Laurence, Pautier, Patricia, Robert, Caroline, Planchard, David, de Botton, Stphane, Scott, Florian, Lemare, Franois, Abbas, May, Guillet, Marilne, Puglisi, Vanessa, Di Palma, Mario, Minvielle, Etienne

Issue&Volume: 2022-04-25

Abstract: Strategies that individualize the care of cancer patients receiving oral anticancer agents offer opportunities to improve treatment adherence and patient care. However, the impact of digital remote monitoring systems in this setting has not been evaluated. Here, we report the results of a phase 3 trial (CAPRI, NCT02828462) to assess the impact of a nurse navigator-led program on treatment delivery for patients with metastatic cancer. Patients receiving approved oral anticancer agents were randomized (1:1) to an intervention combining a nurse navigator-led follow-up system and a web portal–smartphone application on top of usual care, or to usual symptom monitoring at the discretion of the treating oncologist, for a duration of 6months. The primary objective included optimization of the treatment dose. Secondary objectives were grade ≥3 toxicities, patient experience, rates and duration of hospitalization, response and survival, and quality of life. In 559 evaluable patients the relative dose intensity was higher in the experimental arm (93.4% versus 89.4%, P=0.04). The intervention improved the patient experience (Patient Assessment of Chronic Illness Care score, 2.94 versus 2.67, P=0.01), reduced the days of hospitalization (2.82 versus 4.44days, P=0.02), and decreased treatment-related grade ≥3 toxicities (27.6% versus 36.9%, P=0.02). These findings show that patient-centered care through remote monitoring of symptoms and treatment may improve patient outcomes and experience.

DOI: 10.1038/s41591-022-01788-1

Source: https://www.nature.com/articles/s41591-022-01788-1

期刊信息

Nature Medicine：《自然—医学》，创刊于1995年。隶属于施普林格·自然出版集团，最新IF：30.641
官方网址：https://www.nature.com/nm/
投稿链接：https://mts-nmed.nature.com/cgi-bin/main.plex