研究人员利用70个母婴组合的纵向多组学数据，追踪了从怀孕后期到1岁的微生物组和代谢组的共同发展。研究人员发现了大规模母婴移动遗传元件的种间转移，经常涉及与饮食相关的适应性基因。婴儿肠道代谢组的多样性不如母体，但有数百种独特的代谢物和微生物-代谢物关联，这在母体中是检测不到的。接受常规但非广泛水解配方奶粉婴儿的代谢组和血清细胞因子特征与纯母乳喂养的婴儿的不同。总之，这个综合分析扩大了肠道微生物组垂直传播的概念，并为孕晚期和生命早期的母体和婴儿微生物组和代谢组的发展提供了原创性的见解。
据介绍，围产期是认知和免疫系统发展的一个关键窗口，由母婴肠道微生物组及其代谢物促进。
附：英文原文
Title: Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism
Author: Tommi Vatanen, Karolina S. Jabbar, Terhi Ruohtula, Jarno Honkanen, Julian Avila-Pacheco, Heli Siljander, Martin Straar, Sami Oikarinen, Heikki Hyty, Jorma Ilonen, Caroline M. Mitchell, Moran Yassour, Suvi M. Virtanen, Clary B. Clish, Damian R. Plichta, Hera Vlamakis, Mikael Knip, Ramnik J. Xavier
Issue&Volume: 2022/12/22
Abstract: The perinatal period represents a critical window for cognitive and immune system development, promoted by maternal and infant gut microbiomes and their metabolites. Here, we tracked the co-development of microbiomes and metabolomes from late pregnancy to 1 year of age using longitudinal multi-omics data from a cohort of 70 mother-infant dyads. We discovered large-scale mother-to-infant interspecies transfer of mobile genetic elements, frequently involving genes associated with diet-related adaptations. Infant gut metabolomes were less diverse than maternal but featured hundreds of unique metabolites and microbe-metabolite associations not detected in mothers. Metabolomes and serum cytokine signatures of infants who received regular—but not extensively hydrolyzed—formula were distinct from those of exclusively breastfed infants. Taken together, our integrative analysis expands the concept of vertical transmission of the gut microbiome and provides original insights into the development of maternal and infant microbiomes and metabolomes during late pregnancy and early life.
DOI: 10.1016/j.cell.2022.11.023
Source: https://www.cell.com/cell/fulltext/S0092-8674(22)01467-2