论文标题：Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain (COVID-19患者的神经表现——SARS-CoV-2从外周到大脑神经入侵的潜在途径)

期刊： Frontiers of Medicine

作者：Zhengqian Li, Taotao Liu, Ning Yang, Dengyang Han, Xinning Mi, Yue Li, Kaixi Liu, Alain Vuylsteke, Hongbing Xiang, Xiangyang Guo

发表时间：07 May 2020

DOI：10.1007/s11684-020-0786-5

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导读 北京大学第三医院李正迁、郭向阳和华中科技大学同济医学院附属同济医院项红兵等在Frontiers of Medicine 发表综述《COVID-19患者的神经表现：SARS-CoV-2从外周到大脑神经入侵的潜在途径》（Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain）。

目前我们对新型冠状病毒的研究仍处于早期阶段，迄今为止还没有直接证据表明新型冠状病毒入侵了中枢神经系统。我们基于之前对具有神经侵袭倾向的其他呼吸道病毒的发现以及新冠肺炎患者并发的神经症状，重点关注新型冠状病毒可能侵入大脑的潜在途径。

摘 要 由严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)引起的冠状病毒疾病2019(COVID-19)仅在3个月内就引发了全球大流行。除了严重的呼吸窘迫，本文还描述了典型的神经系统表现，表明新型冠状病毒可能是一种被低估的大脑机会性病原体。基于先前对神经侵袭性人类呼吸道冠状病毒的研究，提出在与鼻黏膜、咽喉、气管、下呼吸道、肺泡上皮或胃肠黏膜物理接触后，新型冠状病毒可在宿主中诱导固有和先天免疫反应，包括细胞因子释放增加、组织损伤和对新冠肺炎的高度神经过敏，特别是在肺损伤引起的低氧条件下。在一些免疫受损的个体中，病毒可以通过多种途径侵入大脑，例如脉管系统和外周神经。因此，除了药物治疗，如药物和中药，非药物预防措施，包括口罩和手卫生也是至关重要的。

标题

Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain

作者

Zhengqian Li, Taotao Liu, Ning Yang, Dengyang Han, Xinning Mi, Yue Li, Kaixi Liu, Alain Vuylsteke, Hongbing Xiang, Xiangyang Guo

机构

1. Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China

2. Department of Anaesthesia and Intensive Care, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK

3. Department of Anesthesiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

Corresponding Authors Hongbing Xiang and Xiangyang Guo

摘要

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a global pandemic in only 3 months. In addition to major respiratory distress, characteristic neurological manifestations are also described, indicating that SARS-CoV-2 may be an underestimated opportunistic pathogen of the brain. Based on previous studies of neuroinvasive human respiratory coronaviruses, it is proposed that after physical contact with the nasal mucosa, laryngopharynx, trachea, lower respiratory tract, alveoli epithelium, or gastrointestinal mucosa, SARS-CoV-2 can induce intrinsic and innate immune responses in the host involving increased cytokine release, tissue damage, and high neurosusceptibility to COVID-19, especially in the hypoxic conditions caused by lung injury. In some immune-compromised individuals, the virus may invade the brain through multiple routes, such as the vasculature and peripheral nerves. Therefore, in addition to drug treatments, such as pharmaceuticals and traditional Chinese medicine, non-pharmaceutical precautions, including facemasks and hand hygiene, are critically important.

Cite this article

Zhengqian Li, Taotao Liu, Ning Yang, Dengyang Han, Xinning Mi, Yue Li, Kaixi Liu, Alain Vuylsteke, Hongbing Xiang, Xiangyang Guo. Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain. Front. Med., 2020, 14(5): 533-541 https://doi.org/10.1007/s11684-020-0786-5

https://journal.hep.com.cn/fmd/EN/10.1007/s11684-020-0786-5

https://link.springer.com/article/10.1007/s11684-020-0786-5

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