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研究揭示视觉皮层的高精度编码
作者:小柯机器人 发布时间:2021/4/17 15:30:00

美国HHMI简妮莉亚研究园区Marius Pachitariu研究组揭示视觉皮层中的高精度编码。相关论文于2021年4月14日发表在《细胞》杂志上。

他们在定向解码任务中同时记录了来自小鼠主要视觉皮层(V1)和更高阶视觉区域中的多达50,000个神经元,并分别测量了0.35°和0.37°的刺激识别阈值。这些神经阈值几乎比小鼠报告的行为歧视阈值小100倍。这种差异不能通过刺激特性或唤醒状态来解释。此外,无法通过V1中的神经变异性来解释感官辨别任务期间的行为变异性。相反,与行为相关的神经活动在非感觉性大脑区域网络中动态产生。

这些结果暗示,小鼠的知觉辨别受到下游解码器的限制,而不是受感觉表示中的神经噪声的限制。

此外,视觉皮层中的单个神经元为大脑提供了不可靠的视觉特征估计。尚不清楚单个神经元的变异性是否在较大的神经种群之间相关,从而损害了刺激的整体编码。

附:英文原文

Title: High-precision coding in visual cortex

Author: Carsen Stringer, Michalis Michaelos, Dmitri Tsyboulski, Sarah E. Lindo, Marius Pachitariu

Issue&Volume: 2021-04-14

Abstract: Individual neurons in visual cortex provide the brain with unreliable estimates ofvisual features. It is not known whether the single-neuron variability is correlatedacross large neural populations, thus impairing the global encoding of stimuli. Werecorded simultaneously from up to 50,000 neurons in mouse primary visual cortex (V1)and in higher order visual areas and measured stimulus discrimination thresholds of0.35° and 0.37°, respectively, in an orientation decoding task. These neural thresholdswere almost 100 times smaller than the behavioral discrimination thresholds reportedin mice. This discrepancy could not be explained by stimulus properties or arousalstates. Furthermore, behavioral variability during a sensory discrimination task couldnot be explained by neural variability in V1. Instead, behavior-related neural activityarose dynamically across a network of non-sensory brain areas. These results implythat perceptual discrimination in mice is limited by downstream decoders, not by neuralnoise in sensory representations.

DOI: 10.1016/j.cell.2021.03.042

Source: https://www.cell.com/cell/fulltext/S0092-8674(21)00373-1

期刊信息
Cell:《细胞》,创刊于1974年。隶属于细胞出版社,最新IF:36.216
官方网址:https://www.cell.com/