南方科技大学何川团队开发了硅-立体二氢二苯并西林的催化不对称合成方法，其具有硅-中心-轴向手性接力现象。相关研究成果发表在2021年4月8日出版的《德国应用化学》。

该文报道了一种在Rh催化下不对称合成具有轴向手性六元桥联联二芳基的硅立体二氢二苯并西林的方法。在含有手性二膦配体的Rh（I）催化剂存在下，通过脱氢Csp3H硅酰化反应，可以方便地构建一系列同时含有硅中心手性和轴向手性的二氢二苄西林。

单晶X射线结构的绝对构型分析揭示了一种新颖的硅中心-轴向手性接力现象，对不对称催化和手性光学材料的进一步研究具有一定的启发意义。

附：英文原文

Title: Catalytic Asymmetric Synthesis of Silicon‐Stereogenic Dihydrodibenzosilines: Silicon‐Central to Axial Chirality Relay

Author: Chuan He, Yonghong Guo, Meng-Meng Liu, Xujiang Zhu, Liru Zhu

Issue&Volume: 2021-04-08

Abstract: A Rh‐catalyzed asymmetric synthesis of silicon‐stereogenic dihydrodibenzosilines featuring axially chiral 6‐member‐bridged biaryls is demonstrated. In the presence of Rh(I) catalyst with chiral diphosphine ligand, a wide range of dihydrodibenzosilines containing both silicon‐central and axial chiralities are conveniently constructed in excellent enantioselectivities via dehydrogenative Csp3H silylation. Absolute configuration analysis by single crystal X‐ray structures revealed a novel silicon‐central to axial chirality relay phenomenon, which we believe will inspire further research in the field of asymmetric catalysis and chiroptical materials.

DOI: 10.1002/anie.202103748

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202103748