美国加州大学圣迭戈分校Suzanne Devkota团队发现，肠道菌群向肠系膜脂肪的易位促进人类蠕动脂肪的形成。该项研究成果于2020年9月28日在线发表在《细胞》杂志上。

Title: Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans

Author: Connie W.Y. Ha, Anthony Martin, Gregory D. Sepich-Poore, Baochen Shi, Yizhou Wang, Kenneth Gouin, Gregory Humphrey, Karenina Sanders, Yasiru Ratnayake, Kelvin S.L. Chan, Gustaf Hendrick, J.R. Caldera, Christian Arias, Jacob E. Moskowitz, Shannan J. Ho Sui, Shaohong Yang, David Underhill, Matthew J. Brady, Simon Knott, Kelly Kaihara, Michael J. Steinbaugh, Huiying Li, Dermot P.B. McGovern, Rob Knight, Phillip Fleshner, Suzanne Devkota

Issue&Volume: 2020-09-28

Abstract: A mysterious feature of Crohn’s disease (CD) is the extra-intestinal manifestation of “creeping fat” (CrF), defined as expansion of mesenteric adipose tissue around the inflamed and fibrotic intestine. In the current study, we explore whether microbial translocation in CD serves as a central cue for CrF development. We discovered a subset of mucosal-associated gut bacteria that consistently translocated and remained viable in CrF in CD ileal surgical resections, and identified Clostridium innocuum as a signature of this consortium with strain variation between mucosal and adipose isolates, suggesting preference for lipid-rich environments. Single-cell RNA sequencing characterized CrF as both pro-fibrotic and pro-adipogenic with a rich milieu of activated immune cells responding to microbial stimuli, which we confirm in gnotobiotic mice colonized with C. innocuum. Ex vivo validation of expression patterns suggests C. innocuum stimulates tissue remodeling via M2 macrophages, leading to an adipose tissue barrier that serves to prevent systemic dissemination of bacteria.

DOI: 10.1016/j.cell.2020.09.009

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31150-8