美国洛克菲勒大学C. David Allis和Richard E. Phillips研究组合作发现表观基因组重编程是恶性神经胶质瘤的驱动因素。这一研究成果于2020年9月10日发表在国际顶尖学术期刊《癌细胞》杂志上。

染色质修饰子的突变（通过在染色质上重塑和调节翻译后修饰来塑造表观基因组格局的蛋白质）非常常见，并且经常出现在特定的神经胶质瘤亚型。这表明表观基因组重编程可能是神经胶质瘤的基本驱动力。研究人员描述了神经胶质瘤中破坏的关键染色质调节途径，描述了它们的生理功能，以及目前对它们的失调可能如何促进神经胶质瘤形成的理解。

据了解，恶性神经胶质瘤是中枢神经系统肿瘤，仍然是最难治疗的癌症。外显子组测序揭示了明显的异质性和对神经胶质瘤的分子发病机制的重要见解。

附：英文原文

Title: Epigenomic Reprogramming as a Driver of Malignant Glioma

Author: Richard E. Phillips, Alexey A. Soshnev, C. David Allis

Issue&Volume: 2020-09-10

Abstract: Malignant gliomas are central nervous system tumors and remain among the most treatment-resistantcancers. Exome sequencing has revealed significant heterogeneity and important insightsinto the molecular pathogenesis of gliomas. Mutations in chromatin modifiers—proteinsthat shape the epigenomic landscape through remodeling and regulation of post-translationalmodifications on chromatin—are very frequent and often define specific glioma subtypes.This suggests that epigenomic reprogramming may be a fundamental driver of glioma.Here, we describe the key chromatin regulatory pathways disrupted in gliomas, delineatingtheir physiological function and our current understanding of how their dysregulationmay contribute to gliomagenesis.

DOI: 10.1016/j.ccell.2020.08.008

Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30419-0