葡萄牙里斯本大学Marc Veldhoen、Cristina Ferreira等研究人员合作发现，1型调节性T（Treg）细胞促进CD8⁺组织驻留记忆T细胞的生成。这一研究成果于2020年5月18日在线发表于《自然—免疫学》。

Title: Type 1 T reg cells promote the generation of CD8 + tissue-resident memory T cells

Author: Cristina Ferreira, Leandro Barros, Marta Baptista, Birte Blankenhaus, Andr Barros, Patrcia Figueiredo-Campos, pela Konjar, Alexandra Lain, Nadine Kamenjarin, Ana Stojanovic, Adelheid Cerwenka, Hans C. Probst, Julien C. Marie, Marc Veldhoen

Issue&Volume: 2020-05-18

Abstract: Tissue-resident memory T (TRM) cells, functionally distinct from circulating memory T cells, have a critical role in protective immunity in tissues, are more efficacious when elicited after vaccination and yield more effective antitumor immunity, yet the signals that direct development of TRM cells are incompletely understood. Here we show that type 1 regulatory T (Treg) cells, which express the transcription factor T-bet, promote the generation of CD8+ TRM cells. The absence of T-bet-expressing type 1 Treg cells reduces the presence of TRM cells in multiple tissues and increases pathogen burden upon infectious challenge. Using infection models, we show that type 1 Treg cells are specifically recruited to local inflammatory sites via the chemokine receptor CXCR3. Close proximity with effector CD8+ T cells and Treg cell expression of integrin-β8 endows the bioavailability of transforming growth factor-β in the microenvironment, thereby promoting the generation of CD8+ TRM cells.

DOI: 10.1038/s41590-020-0674-9

Source: https://www.nature.com/articles/s41590-020-0674-9