美国科罗拉多大学Sabrina Spencer、Mingwei Min等研究人员合作发现，母细胞丝裂原参与调控子细胞增殖。该研究于2020年4月2日在线发表于《科学》。

Author: Mingwei Min, Yao Rong, Chengzhe Tian, Sabrina Spencer

Issue&Volume: 2020/04/02

Abstract: Abstract Multi-cellular organisms use mitogens to regulate cell proliferation, yet how fluctuating mitogenic signals are converted into proliferation-quiescence decisions is poorly understood. Here we combine live-cell imaging with temporally controlled perturbations to determine the timescale and mechanisms underlying the system. Contrary to the textbook model that cells only sense mitogen availability in G1, we find that mitogenic signaling is temporally integrated throughout the entire mother cell cycle, and even a one-hour lapse in mitogen signaling can influence cell proliferation over 12 hours later. Protein translation rates serve as the integrator that proportionally converts mitogen history into corresponding levels of Cyclin D in G2 phase of the mother cell, which controls the proliferation-quiescence decision in daughter cells, and thereby couples protein production with cell proliferation.

DOI: 10.1126/science.aay8241

Source: https://science.sciencemag.org/content/early/2020/04/01/science.aay8241