美国埃默里大学医学院的Andrew S. Neish研究团队发现，肠共生乳杆菌能够激活肝Nrf2并防止氧化性肝损伤。相关论文于2020年3月25日在线发表于国际学术期刊《细胞—代谢》上。

Title: Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury

Author: Bejan J. Saeedi, Ken H. Liu, Joshua A. Owens, Sarah Hunter-Chang, Mary C. Camacho, Richard U. Eboka, Bindu Chandrasekharan, Nusaiba F. Baker, Trevor M. Darby, Brian S. Robinson, Rheinallt M. Jones, Dean P. Jones, Andrew S. Neish

Issue&Volume: 2020-03-25

Abstract: Many studies have suggested a role for gut-resident microbes (the “gut microbiome”)in modulating host health; however, the mechanisms by which they impact systemic physiologyremain largely unknown. In this study, metabolomic and transcriptional profiling ofgerm-free and conventionalized mouse liver revealed an upregulation of the Nrf2 antioxidantand xenobiotic response in microbiome-replete animals. Using a Drosophila-based screening assay, we identified members of the genus Lactobacillus capable of stimulating Nrf2. Indeed, the human commensal Lactobacillus rhamnosus GG (LGG) potently activated Nrf2 in the Drosophila liver analog and the murine liver. This activation was sufficient to protect againsttwo models of oxidative liver injury, acetaminophen overdose and acute ethanol toxicity.Characterization of the portal circulation of LGG-treated mice by tandem mass spectrometryidentified a small molecule activator of Nrf2, 5-methoxyindoleacetic acid, producedby LGG. Taken together, these data demonstrate a mechanism by which intestinal microbesmodulate hepatic susceptibility to oxidative injury.

DOI: 10.1016/j.cmet.2020.03.006

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30121-2