广州医科大学龚四堂课题组取得一项新突破。他们的研究分析了儿童SARS-CoV-2感染的临床特征和肠道持续排毒的证据。相关论文于2020年3月13日发表于《自然—医学》杂志上。

研究组对经SARS-CoV-2 RNA实时逆转录PCR检测确诊的10例新冠病毒感染儿童的流行病学和临床研究进行了分析。

这些病例的症状是非特异性的，没有患儿需要呼吸支持或重症监护。与成人感染不同，10例患儿的胸部X光检查未发现明确的肺炎特征。

值得注意的是，即使在鼻咽拭子检测转为阴性后，仍有8名患儿的直肠拭子检测为阳性，这增加了粪便传播的可能性。

附：英文原文

Title: Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding

Author: Yi Xu, Xufang Li, Bing Zhu, Huiying Liang, Chunxiao Fang, Yu Gong, Qiaozhi Guo, Xin Sun, Danyang Zhao, Jun Shen, Huayan Zhang, Hongsheng Liu, Huimin Xia, Jinling Tang, Kang Zhang, Sitang Gong

Issue&Volume: 2020-03-13

Abstract: We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. Chest X-rays lacked definite signs of pneumonia, a defining feature of the infection in adult cases. Notably, eight children persistently tested positive on rectal swabs even after nasopharyngeal testing was negative, raising the possibility of fecal–oral transmission.

DOI: 10.1038/s41591-020-0817-4

Source: https://www.nature.com/articles/s41591-020-0817-4