近日，中国南方医科大学毛琛教授及其研究团队分析了习惯性补充鱼油与心血管结局和全因死亡率的相关性。相关论文发表在2020年3月4日出版的《英国医学杂志》上。

为了评估习惯性补充鱼油与心血管疾病（CVD）和死亡率的关系，研究组基于英国生物库进行了一项大型前瞻性队列研究 。2006-2010年间，共纳入427678名年龄为40-69岁的参与者，基线时均没有CVD或癌症，并随访至2018年底。

有133488名（31.2%）参与者习惯性补充鱼油。经多因素校正后，习惯性补充鱼油与不补充鱼油的全因死亡的风险比为0.87，CVD死亡为0.84，CVD事件为0.93。此前患有高血压的患者中，CVD事件的关联似乎更强。

总之，习惯性补充鱼油似乎可降低全因和CVD死亡的风险，并在普通人群中对预防CVD事件提供了些微益处。

附：英文原文

Title: Associations of habitual fish oil supplementation with cardiovascular outcomes and all cause mortality: evidence from a large population based cohort study

Author: Zhi-Hao Li, Wen-Fang Zhong, Simin Liu, Virginia Byers Kraus, Yu-Jie Zhang, Xiang Gao, Yue-Bin Lv, Dong Shen, Xi-Ru Zhang, Pei-Dong Zhang, Qing-Mei Huang, Qing Chen, Xian-Bo Wu, Xiao-Ming Shi, Dong Wang, Chen Mao

Issue&Volume: 2020/03/04

Abstract: Objectives To evaluate the associations of habitual fish oil supplementation with cardiovascular disease (CVD) and mortality in a large prospective cohort.Design Population based, prospective cohort study.Setting UK Biobank.Participants A total of 427678 men and women aged between 40 and 69 who had no CVD or cancer at baseline were enrolled between 2006 and 2010 and followed up to the end of 2018.Main exposure All participants answered questions on the habitual use of supplements, including fish oil.Main outcome measures All cause mortality, CVD mortality, and CVD events.Results At baseline, 133438 (31.2%) of the 427678 participants reported habitual use of fish oil supplements. The multivariable adjusted hazard ratios for habitual users of fish oil versus non-users were 0.87 (95% confidence interval 0.83 to 0.90) for all cause mortality, 0.84 (0.78 to 0.91) for CVD mortality, and 0.93 (0.90 to 0.96) for incident CVD events. For CVD events, the association seemed to be stronger among those with prevalent hypertension (P for interaction=0.005).Conclusions Habitual use of fish oil seems to be associated with a lower risk of all cause and CVD mortality and to provide a marginal benefit against CVD events among the general population.

DOI: 10.1136/bmj.m456

Source: https://www.bmj.com/content/368/bmj.m456