美国加州大学旧金山分校Ronald D. Vale研究团队在研究中取得进展。他们研制出一种6纳米的超光稳定型DNA分子，可用于荧光成像。该项研究成果于2020年3月16日在线发表在《自然—方法学》杂志上。

Title: A 6-nm ultra-photostable DNA FluoroCube for fluorescence imaging

Author: Stefan Niekamp, Nico Stuurman, Ronald D. Vale

Issue&Volume: 2020-03-16

Abstract: Photobleaching limits extended imaging of fluorescent biological samples. We developed DNA-based ‘FluoroCubes’ that are similar in size to the green fluorescent protein, have single-point attachment to proteins, have a ~54-fold higher photobleaching lifetime and emit ~43-fold more photons than single organic dyes. We demonstrate that DNA FluoroCubes provide outstanding tools for single-molecule imaging, allowing the tracking of single motor proteins for >800 steps with nanometer precision.

DOI: 10.1038/s41592-020-0782-3

Source: https://www.nature.com/articles/s41592-020-0782-3