法国巴黎大学Serge H. Luquet和Giuseppe Gangarossa团队的最新研究发现，循环的甘油三酯通过表达DRD2的神经元调控多巴胺（DA）相关的行为。这一研究成果在线发表在2020年3月5日出版的国际学术期刊《细胞-代谢》上。

研究人员发现哺乳动物餐后代谢的重要标志甘油三酸酯（TGs）可被中皮层皮质（MCL）系统代谢和调控与DA相关的行为，这是通过涉及脂蛋白脂肪酶（LPL）的作用参与控制表达多巴胺受体亚型2（DRD2）神经元的活性来完成的。

此外，该研究表明，在人类中餐后TG的浮动可调节个体大脑对食物的反应，这些个体可能有遗传上减弱DRD2信号的风险。

总的来说，这些发现揭示了一种新的机制，即餐食中的TG可以直接改变奖励回路中的信号传导来调节行为；这提供了一个新的机制基础，即能量丰富的饮食可能导致DA信号传导的（不良）适应，这可能造成奖励不足和强迫行为。

研究人员表示，能量丰富的食物会改变中皮层皮质系统中多巴胺能的传递，并可能导致奖励功能障碍、强迫性进食和体重增加。然而，何种营养成分影响MCL电路仍有待研究。

附：英文原文

Title: Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons

Author: Chloé Berland, Enrica Montalban, Elodie Perrin, Mathieu Di Miceli, Yuko Nakamura, Maud Martinat, Mary Sullivan, Xue S. Davis, Mohammad Ali Shenasa, Claire Martin, Stefania Tolu, Fabio Marti, Stephanie Caille, Julien Castel, Sylvie Perez, Casper Gravesen Salinas, Chloé Morel, Jacob Hecksher-Srensen, Martine Cador, Xavier Fioramonti, Matthias H. Tschp, Sophie Layé, Laurent Venance, Philippe Faure, Thomas S. Hnasko, Dana M. Small, Giuseppe Gangarossa, Serge H. Luquet

Issue&Volume: 2020-03-05

Abstract: Energy-dense food alters dopaminergic (DA) transmission in the mesocorticolimbic (MCL)system and can promote reward dysfunctions, compulsive feeding, and weight gain. Yetthe mechanisms by which nutrients influence the MCL circuitry remain elusive. Here,we show that nutritional triglycerides (TGs), a conserved post-prandial metabolicsignature among mammals, can be metabolized within the MCL system and modulate DA-associatedbehaviors by gating the activity of dopamine receptor subtype 2 (DRD2)-expressingneurons through a mechanism that involves the action of the lipoprotein lipase (LPL).Further, we show that in humans, post-prandial TG excursions modulate brain responsesto food cues in individuals carrying a genetic risk for reduced DRD2 signaling. Collectively,these findings unveil a novel mechanism by which dietary TGs directly alter signalingin the reward circuit to regulate behavior, thereby providing a new mechanistic basisby which energy-rich diets may lead to (mal)adaptations in DA signaling that underliereward deficit and compulsive behavior.

DOI: 10.1016/j.cmet.2020.02.010

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30069-3